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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS198 描述 Anti-Spred-2 Antibody Alternate Names - Sprouty-related, EVH1 domain-containing protein 2
背景信息 The Sprouty/Spread family of proteins contains three members, which share high sequence homology for the cysteine-rich domain (CRD), and are shown to inhibit Ras/ERK signaling. Along with its other family members, Spred-2 inhibits Ras/MAP kinase activity (mediated by the epidermal growth factor receptor and the fibroblast growth factor receptor) by binding to Ras and thereby preventing Raf phosphorylation. Like Spred-1, Spred-2 competes with substrates Tau and STAT3 for the DYRK1a kinase domain and thereby inhibits DYRK1a substrate phosphorylation. It is reported that Spred-2 appears to be involved in cytoplasmic vesicle transport and in other metabolic signaling. 产品信息 格式 Affinity Purified 控制 - PC-3 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Spred-2 Antibody is validated for use in WB for the detection of Spred-2. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Spred-2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Demonstrated to react with Human.
Other homologies: Mouse and Rat (89% sequence homology).抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001121682
Entrez基因汇总 SPRED2 is a member of the Sprouty/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see Entrez Gene website MAPK1; MIM 176948). (Nonami, A., et al. (2004). 279(50):52543-52551.) 基因符号 - SPRED2
纯化方法 Affinity Purified UniProt编号 - Q7Z698
UniProt汇总 FUNCTION: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase.
SUBUNIT STRUCTURE: Interacts with Ras. Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle > secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note: Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules.
TISSUE SPECIFICITY: Expressed in liver, skin, small intestine, salivary gland and prostate.产品使用声明 质量保证 Evaluated by Western Blot in PC-3 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Spred-2 in 10 µg of PC-3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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下一件merck millipore产品：merck millipore,默克密理博,AB5986,Anti-Tyrosine Hydroxylase Antibody
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