merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5486,Anti-Macrophage Scavenger Receptor Type 1 Antibody

  • merck millipore,默克密理博,AB5486,Anti-Macrophage Scavenger Receptor Type 1 Antibody

    产品名称：Anti-Macrophage Scavenger Receptor Type 1 Antibody
    产品型号：AB5486
    Detect Macrophage Scavenger Receptor Type 1 using this Anti-Macrophage Scavenger Receptor Type 1 Antibody validated for use in ELISA, WB, IH(P).

    merck millipore,默克密理博,AB5486,Anti-Macrophage Scavenger Receptor Type 1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5486,Anti-Macrophage Scavenger Receptor Type 1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISAGtSerumPolyclonal Antibody
    描述
    产品目录编号 AB5486
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Macrophage Scavenger Receptor Type 1 Antibody
    Alternate Names
    • MSR
    背景信息 Macrophage scavenger receptors (MSR) are membrane glycoproteins that mediate the recognition and uptake of a wide variety of negatively charged macromolecules. There are two types of these receptors that differ in the C-terminal region. MSR has a key role in scavenging a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of MSR is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Ab deposition in Alzheimer's disease (AD).The observation that the 4 allele of the apolipoprotein E gene is associated with an increased risk for AD has lead to the investigation of lipoprotein metabolism in the brain of AD patients. The type I MSR has been found to be expressed on microglia and Mato cells, but not astrocytes or neurons. In AD brain, MSR type I is strongly expressed by microglia cells that are associated with senile plaques. Because the senile plaques contain AGEs, which are a source of free radicals that could result in oxidative damage to the brain, MSR may have a role in mediating the endocytosis of AGEs.
    产品信息
    格式 Serum
    演示 Goat serum. Liquid containing 0.01% thimerosal.
    应用
    应用 Detect Macrophage Scavenger Receptor Type 1 using this Anti-Macrophage Scavenger Receptor Type 1 Antibody validated for use in ELISA, WB, IH(P).
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Immunohistochemistry: 1:200 on paraffin embedded, formalin fixed human brain.

    Western blot: 1:2,000

    ELISA against immunogen peptide: 1:97,000

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide that corresponds to amino acids 325-342 of the C-terminus of the human MSR type I.
    宿主 Goat
    特异性 Specific for human macrophage scavenger receptor type I (MSR type I). This antibody immunolabels amyloid plaques in formalin-fixed paraffin sections from Alzheimer's Disease (AD) brain.
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_138716.2
    • NM_002445.3
    • NM_138715.2
    Entrez基因汇总 This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
    基因符号
    • CD204
    • MSR1
    • SR-A
    • SCARA1
    • phSR2
    • phSR1
    UniProt编号
    • P21757
    UniProt汇总 FUNCTION: SwissProt: P21757 # Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).
    SIZE: 451 amino acids; 49762 Da
    SUBUNIT: Homotrimer.
    SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
    SIMILARITY: SwissProt: P21757 ## Contains 1 collagen-like domain. & Contains 1 SRCR domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,AB5486,Anti-Macrophage Scavenger Receptor Type 1 Antibody

上一件merck millipore产品：merck millipore,默克密理博,SF-1110,miR-290-3p; Mouse, Cyanine 5, RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,07-1237,Anti-phospho-C-Ret (Ser 696) Antibody


相关产品

merck millipore,默克密理博,07-018,Anti-phospho-p70 S6 Kinase (Thr412) Antibody merck millipore,默克密理博,07-018,Anti-phospho-p70 S6 Kinase (Thr412) Antibody

merck millipore,默克密理博,04-1133,Anti-TIMP-1 Antibody, clone EP1549RY, rabbit monoclonal merck millipore,默克密理博,04-1133,Anti-TIMP-1 Antibody, clone EP1549RY, rabbit monoclonal

merck millipore,默克密理博,ABN504,Anti-CTBS Antibody merck millipore,默克密理博,ABN504,Anti-CTBS Antibody

merck millipore,默克密理博,112251,α₁-Acid Glycoprotein, Human Plasma merck millipore,默克密理博,112251,α₁-Acid Glycoprotein, Human Plasma

merck millipore,默克密理博,SF-1110,miR-290-3p; Mouse, Cyanine 5, RNA Detection Probe,SmartFlare merck millipore,默克密理博,SF-1110,miR-290-3p; Mouse, Cyanine 5, RNA Detection Probe,SmartFlare

merck millipore,默克密理博,07-1237,Anti-phospho-C-Ret (Ser 696) Antibody merck millipore,默克密理博,07-1237,Anti-phospho-C-Ret (Ser 696) Antibody

merck millipore,默克密理博,AB5769,Anti-D-Aspartate Antibody merck millipore,默克密理博,AB5769,Anti-D-Aspartate Antibody

merck millipore,默克密理博,AB8201,Anti-Collagen Type IV Antibody merck millipore,默克密理博,AB8201,Anti-Collagen Type IV Antibody

merck millipore,默克密理博,524488,Phloretin - CAS 60-82-2 - Calbiochem merck millipore,默克密理博,524488,Phloretin - CAS 60-82-2 - Calbiochem

merck millipore,默克密理博,ABT350,Anti-GIPC1 Antibody merck millipore,默克密理博,ABT350,Anti-GIPC1 Antibody


whatman,沃特曼,nalgene,耐洁,merck millipore,默克密理愽,sartorius,赛多利斯,pall,颇尔
thermo fisher,赛默飞世尔,GE,MN,macherey-nagel,advantec,wheaton,brand,普兰德,welch,airtech


上海羽令过滤器材有限公司版权所有 Copyright ©  www.yl-guolv.com  Powered by 羽令集团—信息技术部