- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M, H IH(P) Rb Purified Polyclonal Antibody 描述 产品目录编号 AB8201 Replaces AB756P 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Collagen Type IV Antibody 背景信息 Collagen is a long, fibrous structural protein whose function is quite different from the globular proteins such as enzymes. Tough bundles of collagen called collagen fibers are a major component of the extracellular matrix that supports most tissues and gives cells structure from the outside, but collagen is also found inside certain cells. Collagen has great tensile strength, and the main component of fascia, cartilage, ligaments, tendons, bone, and teeth. It strengthens blood vessels and plays a role in tissue development. There are 28 types of collagen described in literature.
Collagen Type IV forms the structural integrity of the basement membrane and is present in the placenta and eye lens. It also serves as part of the filtration system in capillaries and the glomeruli of nephron in the kidney. Collagen IV may inhibit endothelial cell proliferation and angiogenesis via mechanisms involving cell surface proteoglycans and the alpha and beta integrins of endothelial cells.
产品信息 格式 Purified 控制 - Human intestinal tissue (basement membrane of the lamina propria)
演示 Purified in buffer containing 0.02 M Sodium Phosphate; 150 mM NaCl and 0.1% Sodium Azide. 应用 应用 Anti-Collagen Type IV Antibody is an antibody against Collagen Type IV for use in IH(P). 主要应用 - Immunohistochemistry (Paraffin)
不建议的应用 - Western Blotting
应用说明 Suggested dilutions:
Immunohistochemistry: 1:50-1:500 dilution for formalin-fixed, paraffin-embedded tissues. Recommended pretreatment using citrate buffer, pH 6.0 and high heat epitope retrieval techniques.
Optimal working conditions must be determined by end user.生物信息 免疫原品种 Collagen IV native protein purified from murine sarcoma basement membrane. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes native Collagen Type IV 同种型 IgG 品种反应性 RatMouseHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_009931.2
Entrez基因汇总 This gene encodes the major type IV alpha collagen chain of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. 基因符号 - COL4A1
纯化方法 Protein G chromatography UniProt编号 - P02463
UniProt汇总 FUNCTION: Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
SUBUNIT: There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
TISSUE: Brain, Eye, Heart, and Placenta产品使用声明 质量保证 Routinely evaluated by Immunohistochemistry onparaffin-embedded human intestinal tissue. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of shipment. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,AB5769,Anti-D-Aspartate Antibody
下一件merck millipore产品：merck millipore,默克密理博,524488,Phloretin - CAS 60-82-2 - Calbiochem
相关产品
merck millipore,默克密理博,112251,α₁-Acid Glycoprotein, Human Plasma
merck millipore,默克密理博,SF-1110,miR-290-3p; Mouse, Cyanine 5, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,AB5486,Anti-Macrophage Scavenger Receptor Type 1 Antibody
merck millipore,默克密理博,07-1237,Anti-phospho-C-Ret (Ser 696) Antibody
merck millipore,默克密理博,AB5769,Anti-D-Aspartate Antibody
merck millipore,默克密理博,524488,Phloretin - CAS 60-82-2 - Calbiochem
merck millipore,默克密理博,ABT350,Anti-GIPC1 Antibody
merck millipore,默克密理博,AB976,Anti-Thyroid Stimulating Hormone Antibody
merck millipore,默克密理博,MABE429,Anti-UBE2I Antibody, clone 1B10
merck millipore,默克密理博,UFC703008,Centricon Plus-70，Ultracel-PL 超滤膜，30 kDa