merck millipore,默克密理博,524488,Phloretin - CAS 60-82-2

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merck millipore,默克密理博,524488,Phloretin - CAS 60-82-2 - Calbiochem
产品名称：Phloretin - CAS 60-82-2 - Calbiochem
产品型号：524488
A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM).

merck millipore,默克密理博,524488,Phloretin - CAS 60-82-2 - Calbiochem

产品介绍

merck millipore,默克密理博,524488,Phloretin - CAS 60-82-2 - Calbiochem

重要规格表

经验配方	CAS号
C₁₅H₁₄O₅	60-82-2

描述
概述	A cell-permeable inhibtor of protein kinase C (IC₅₀ = 20-50 µM). Activates Ca²⁺-activated K⁺ channels in amphibian myelinated nerve fibers at micromolar concentrations. An inhibitor of myo-inositol uptake. Also inhibits L-type Ca²⁺ channel activity. A potent inhibitor of 5′-iodothyronine deiodinase. Antagonist of prostaglandin F_2α receptors linked to phospholipase C in astrocytes.
产品目录编号	524488
品牌系列	Calbiochem®
同义词	2ʹ,4ʹ,6ʹ-Trihydroxy-3-p-hydroxyphenylpropiophenone

参考
参考	Berry, G.T., et al. 1994. Pediat. Res. 35, 141. Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167. Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410. Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699. Kitanaka, J., et al. 1993. J. Neurochem. 60, 704. Wang, X., et al. 1993. Biochem. J. 290, 249. Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219. Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.

参考

Berry, G.T., et al. 1994. Pediat. Res. 35, 141.
Koh, D.S., et al. 1994. Neurosci. Lett. 165, 167.
Morreale de Escobar, G., et al. 1994. Endocrinology 134, 2410.
Prevarskaya, N., et al. 1994. Mol. Cell. Neurosci. 5, 699.
Kitanaka, J., et al. 1993. J. Neurochem. 60, 704.
Wang, X., et al. 1993. Biochem. J. 290, 249.
Benga, G., et al. 1992. Eur. J. Cell Biol. 59, 219.
Jordan, M.L., and Wright, J. 1991. J. Surg. Res. 50, 569.

产品信息
CAS号	60-82-2
具有ATP竞争性	N
形式	White solid
Hill配方	C₁₅H₁₄O₅
化学配方	C₁₅H₁₄O₅
Molar Mass	274.3
可逆	N
结构配方图像

生物信息
主靶	PKC
主靶IC₅₀	20-50 µM against protein kinase C
纯度	≥97% by TLC

理化信息
细胞可渗透	Y
溶解度	Acetone, EtOH, or MeOH

安全信息
R相	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S相	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Irritant
储存	-20°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Ethanol stock solutions are stable for up to 1 month at -20°C.