merck millipore,默克密理愽
  • merck millipore,默克密理博,07-1237,Anti-phospho-C-Ret (Ser 696) Antibody

  • merck millipore,默克密理博,07-1237,Anti-phospho-C-Ret (Ser 696) Antibody

    产品名称：Anti-phospho-C-Ret (Ser 696) Antibody
    产品型号：07-1237
    Anti-phospho-C-Ret (Ser 696) Antibody detects level of phospho-C-Ret (Ser 696) & has been published & validated for use in WB, IH(P).

    merck millipore,默克密理博,07-1237,Anti-phospho-C-Ret (Ser 696) Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-1237,Anti-phospho-C-Ret (Ser 696) Antibody

    Replacement Information
    Replacement Information 07-1237 is a recommended replacement for AB9638

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-1237
    Replaces AB9638
    描述 Anti-phospho-C-Ret (Ser 696) Antibody
    Alternate Names
    • Ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
    • Hirschsprung disease 1
    • Proto-oncogene tyrosine-protein kinase receptor ret precursor
    • RET transforming sequence
    • Cadherin family member 12
    • Hydroxyaryl-protein kinase
    • Multiple endocrine neoplasia and medullary thyroid carcinoma 1
    • Oncogene RET
    • Receptor tyrosine kinase
    • Ret proto-oncogene
    • Ret proto-oncogene (multiple endocrine neoplasia MEN2A, MEN2B and medullary thyroid carcinoma 1, Hirschsprung disease)
    • MEN2B and medullary thyroid carcinoma 1
    • Hirschsprung disease)
    背景信息 Ret is a tyrosine kinase receptor involved in the activation of several signaling pathways including the PLC gamma, Ras, JNK and inositol phosphate pathways. Ret mutations have been shown to be causative in several diseases, including Hirschsprung's disease (HD), papillary thyroid carcinoma, and multiple endocrine neoplasia (MEN) 2A, MEN 2B, and familial medullary thyroid carcinoma.
    产品信息
    格式 Affinity Purified
    控制
    • Huvec Cell Lysate, GDNF stimulated Neuro-2A cell or TT medullary thyroid carcinoma cells
    演示 Purified rabbit polyclonal IgG in buffer containing Dulbecco's PBS (without Mg2+ and Ca2+), pH 7.3 with 1.0 mg/mL BSA and 0.05% sodium azide.
    应用
    应用 Anti-phospho-C-Ret (Ser 696) Antibody detects level of phospho-C-Ret (Ser 696) & has been published & validated for use in WB, IH(P).
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry(paraffin):
    Representative testing from a previous lot.
    Optimal Staining of c-Ret With Citrate pH 6.0 Epitope Retrieval: Colorectal Cancer
    生物信息
    免疫原品种 Synthetic peptide of amino acids surrounding the phosphoSerine 696 site of human c-ret.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 c-Ret phosphoSerine 696. The antibody recognizes a protein of ~170 kDa corresponding to c-Ret pSer696 in lysates from Neuro-2A cells stimulated with GDNF.
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Human. Other species have not been tested. The immunogen has 92% homology with rat and 83% with mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_020630.4
    Entrez基因汇总 This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
    基因符号
    • EC 2.7.10.1
    • RET
    • HSCR1
    • MEN2A
    • PTC
    • CDHF12
    • RET51
    • RET-ELE1
    • C-ret
    • MTC1
    • MEN2B
    修改
    • Phosphorylation
    纯化方法 Affinity Purfied
    UniProt编号
    • P07949
    UniProt汇总 FUNCTION: SwissProt: P07949 # Probable receptor with tyrosine-protein kinase activity; important for development.
    SIZE: 1114 amino acids; 124319 Da
    SUBUNIT: Phosphorylated form interacts with the PBT domain of DOK2, DOK4 and DOK5 (By similarity).
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    PTM: Phosphorylated. & Autophosphorylated on C-terminal tyrosine residues upon ligand stimulation.
    DISEASE: SwissProt: P07949 # Defects in RET are a cause of pheochromocytoma [MIM:171300]. The pheochromocytomas are catecholamine-producing, chromaffin tumors that arise in the adrenal medulla in 90% of cases. In the remaining 10% of cases, they develop in extra- adrenal sympathetic ganglia and may be referred to as paraganglioma. Pheochromocytoma usually presents with hypertension. Approximately 10% of pheochromocytoma is hereditary. The genetic basis for most cases of non-syndromic familial pheochromocytoma is unknown. & Defects in RET are the cause of medullary thyroid carcinoma (MTC) [MIM:155240]. MTC is a rare tumor derived from the C cells of the thyroid. Three hereditary forms are known, that are transmitted in an autosomal dominant fashion: (a) multiple neoplasia type 2A (MEN2A), (b) multiple neoplasia type IIB (MEN2B) and (c) familial MTC (FMTC), which occurs in 25-30% of MTC cases and where MTC is the only clinical manifestation. & Defects in RET are the cause of multiple neoplasia type IIA (MEN2A) [MIM:171400]; also called multiple neoplasia type II (MEN2). MEN2A, the most frequent form of MTC, is an inherited cancer syndrome characterized by MTC, phaeochromocytoma and/or hyperparathyroidism. & Defects in RET are the cause of multiple neoplasia type IIB (MEN2B) [MIM:162300]. MEN2B is an uncommon inherited cancer syndrome characterized by predisposition to MTC and phaeochromocytoma which is associated with marfanoid habitus, mucosal neuromas, skeletal and ophtalmic abnormalities, and ganglioneuromas of the intestine tract. Then the disease progresses rapidly with the development of metastatic MTC and a pheochromocytome in 50% of cases. & Defects in RET are a cause of Hirschsprung disease (HSCR) [MIM:142623]. HSCR is a genetic disorder of neural crest development characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. Occasionally, MEN2A or FMTC occur in association with HSCR. & Chromosomal aberrations involving RET are a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene; inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene; translocation t(10;14)(q11;q32) with GOLGA5 generates the RET/GOLGA5 (PTC5) oncogene; translocation t(8;10)(p21.3;q11.2) with PCM1 generates the PCM1/RET fusion; translocation t(6;10)(p21.3;q11.2) with RFP generates the Delta RFP/RET oncogene; translocation t(1;10)(p13;q11) with TRIM33 generates the TRIM33/RET (PTC7) oncogene; translocation t(7;10)(q32;q11) with TIF1 generates the TIF1/RET (PTC6) oncogene. The PTC5 oncogene has been found in 2 cases of PACT in children exposed to radioactive fallout after Chernobyl. & Defects in RET are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia. & Defects in RET may be a cause of colorectal cancer (CRC) [MIM:114500].
    SIMILARITY: SwissProt: P07949 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 1 cadherin domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on pervanadate treated Huvec lysates.

    Western Blot Analysis: 1:500 dilution of this lot detected phosphorylated c-RET (SER696) on 10 μg of pervanadate treated Huvec lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable at -80°C in undilutedform for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self defrosting freezer.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-1237,Anti-phospho-C-Ret (Ser 696) Antibody

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