merck millipore,默克密理博,04-1133,Anti-TIMP-1 Antibody, clone EP1549RY, rabbit monoclonal

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merck millipore,默克密理博,04-1133,Anti-TIMP-1 Antibody, clone EP1549RY, rabbit monoclonal
产品名称：Anti-TIMP-1 Antibody, clone EP1549RY, rabbit monoclonal
产品型号：04-1133
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-TIMP-1 Antibody, clone EP1549RY, Rabbit is an a More>>

merck millipore,默克密理博,04-1133,Anti-TIMP-1 Antibody, clone EP1549RY, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-1133,Anti-TIMP-1 Antibody, clone EP1549RY, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Unpurified	Monoclonal Antibody

描述
产品目录编号	04-1133
描述	Anti-TIMP-1 Antibody, clone EP1549RY, rabbit monoclonal
Alternate Names	tissue inhibitor of metalloproteinase 1 (erythroid<br />potentiating activity, collagenase inhibitor) Collagenase inhibitor Erythroid-potentiating activity Fibroblast collagenase inhibitor TIMP metallopeptidase inhibitor 1 Tissue inhibitor of metalloproteinases erythroid potentiating activity tissue inhibitor of metalloproteinase 1
背景信息	Tissue Inhibitors of Metalloproteinases (TIMPs) inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-1 and TIMP-2 have similar properties, specifically in inhibiting enzymes of matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP-1 forms a complex of 1:1 stoichiometry with activated interstitial collagenase, activated stromelysin, active form of 72 kDa type IV collagenase (also known as MMP-2), and latent and active forms 92 kDa Type IV collagenase (also known as MMP-9 or gelatinase B). TIMP-1 levels in quiescent cells and tissues are low (pg/ml), and stimulation with the phorbol ester TPA or protein concentration is often needed to visualize protein bands. In addition, cell types differ greatly in the amount of TIMP-1 produced.

产品信息
格式	Unpurified
控制	Recombinant protein
演示	Rabbit Monoclonal in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl containing 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-TIMP-1 Antibody, clone EP1549RY, Rabbit is an antibody against TIMP-1 for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	Synthetic peptide corresponding to residues in the C-terminal region of human TIMP-1.
表位	C-terminus
克隆	EP1549RY
宿主	Rabbit
特异性	This antibody recognizes TIMP-1.
同种型	IgG
品种反应性	Human
Species Reactivity Note	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	P01033
基因符号	TIMP-1 CLGI EPA EPO FLJ90373 HCI OTTHUMP00000023214 TIMP
纯化方法	Unpurified
UniProt编号	P01033
UniProt汇总	FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. SUBCELLULAR LOCATION: Secreted. PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds. SEQUENCE SIMILARITIES: Belongs to the protease inhibitor I35 (TIMP) family. [View classification] Contains 1 NTR domain.

产品使用声明
质量保证	Evaluated by Western Blot. Western Blot Analysis: 1:100-500 dilution of this antibody was used to detect TIMP-1.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20ºC from date of receipt.

Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.