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merck millipore,默克密理博,AB5460-50UL,Anti-Acid Sensitive Ion Channel 2 Antibody, neuronal
产品名称：Anti-Acid Sensitive Ion Channel 2 Antibody, neuronal
产品型号：AB5460-50UL
Anti-Acid Sensitive Ion Channel 2 Antibody, neuronal is an antibody against Acid Sensitive Ion Channel 2 for use in WB.
merck millipore,默克密理博,AB5460-50UL,Anti-Acid Sensitive Ion Channel 2 Antibody, neuronal
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5460-50UL 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Acid Sensitive Ion Channel 2 Antibody, neuronal Alternate Names - ACCN1
- ASIC2
- Degenerin
- Nueronal Amiloride-sensitive Cation Channel 1
- BNaC1
产品信息 格式 Affinity Purified 控制 - CONTROL ANTIGEN: Included free of charge with the antibody is 40 μg of control antigen (lyophilized powder). The antigen should be reconstituted with 100 μL of deionized water. For negative control, preincubate 1 μg of purified peptide with 1 μg of antibody for one hour at room temperature. Optimal concentrations must be determined by the end user.
演示 Affinity purified immunoglobulin. Lyophilized from PBS, pH 7.4, containing 1% BSA, 5% sucrose and 0.025% sodium azide. Reconstitute with 50 μL of sterile distilled water. Centrifuge antibody preparation before use (10,000 x g for 5 min). 应用 应用 Anti-Acid Sensitive Ion Channel 2 Antibody, neuronal is an antibody against Acid Sensitive Ion Channel 2 for use in WB. 主要应用 - Western Blotting
应用说明 Western blotting: 1:200 using ECL on rat brain membranes.
Dilutions should be made using a carrier protein such as BSA (1-3%).
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Highly purified peptide corresponding to residues 2-18 of rat or human ASIC2 (Accession Q16515). 表位 neuronal 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes ASIC2. The epitope used for the immunogen is specific for ASIC2 and is not similar to any other known protein. The epitope is not specific for ASIC2b (MDEG2) splice variant.
SPECIES REACTIVITIES: It is expected that the antibody will also react with mouse due to immunogen sequence homology (100%). Reactivity with other species has not yet been tested.品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_183377.1
- NM_001094.4
Entrez基因汇总 This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. 基因符号 - ASIC2
- ACCN1
- degenerin
- BNC1
- hBNaC1
- MDEG
- BNaC1
- ACCN
- ASIC2a
- BNAC1
UniProt编号 - Q16515
UniProt汇总 FUNCTION: SwissProt: Q16515 # Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
SIZE: 512 amino acids; 57709 Da
SUBUNIT: Homotetramer or heterotetramer with other ASIC proteins (Probable). Interacts with STOM (By similarity). Interacts with PRKCABP and ACCN3.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity). Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes (By similarity).
TISSUE SPECIFICITY: Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.
SIMILARITY: SwissProt: Q16515 ## Belongs to the amiloride-sensitive sodium channel family.
MISCELLANEOUS: Inhibited by anti-inflammatory drugs like salicylic acid (By similarity). Regulated by Zn(2+).产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain lyophilized material at -20°C for up to 6 months. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. 包装信息 数量 50 µL
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