merck millipore,默克密理愽
  • merck millipore,默克密理博,AB15014,Anti-Glycine Receptor α3 subunit Antibody

  • merck millipore,默克密理博,AB15014,Anti-Glycine Receptor α3 subunit Antibody

    产品名称：Anti-Glycine Receptor α3 subunit Antibody
    产品型号：AB15014
    Anti-Glycine Receptor α3 subunit Antibody detects level of Glycine Receptor α3 subunit & has been published & validated for use in IH & WB.

    merck millipore,默克密理博,AB15014,Anti-Glycine Receptor α3 subunit Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB15014,Anti-Glycine Receptor α3 subunit Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWB, IHCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB15014
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Glycine Receptor α3 subunit Antibody
    Alternate Names
    • ligand gated ion channel
    • glycine receptor, alpha-3 polypeptide
    • glycine receptor, alpha 3
    • glycine receptor alpha 3 subunit
    • glycine receptor alpha 3 subunit
    背景信息 Glycine receptor α3 subunit, also known as GLRA3, belongs to the ligand-gated ion channel family. Glycine functions as a inhibitory neurotransmitter throughout the CNS of mammals. The Glycine receptor is a neurotransmitter ligand-gated ion channel. GLRA3 is a pentamer that is composed of ligand binding alpha and structural beta subunits. When glycine binds to the receptor, chloride conductance increases which produces hyperpolarization. It is expressed in the hippocampus, olfactory bulb, and cerebellum. GLRA3 may be involved in human and murine neurological disorders.
    产品信息
    格式 Purified
    控制
    • Fetal human brain tissue lysate
    演示 Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Glycine Receptor α3 subunit Antibody detects level of Glycine Receptor α3 subunit & has been published & validated for use in IH & WB.
    主要应用
    • Western Blotting
    • Immunohistochemistry
    应用说明 Immunohistochemistry Analysis: 1:100-500 dilution from a previous lot detected Glycine Receptor α3 subunit in mouse spinal cord and mouse eye tissue.
    生物信息
    免疫原品种 This antibody is generated from rabbits immunized with a KLH conjugated linear peptide selected from residues surrounding the C-terminus of human Glycine Receptor α3 subunit.
    表位 C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes Glycine Receptor α3 subunit.
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse. Rat (92%) homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_006520.2
    基因符号
    • GLRA3
    纯化方法 Affinity Purfied
    UniProt编号
    • O75311
    UniProt汇总 FUNCTION: SwissProt: O75311 # The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).
    SIZE: 464 amino acids; 53800 Da
    SUBUNIT: Pentamer composed of alpha and beta subunits (By similarity).
    SUBCELLULAR LOCATION: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Widely distributed throughout the central nervous system.
    DOMAIN: SwissProt: O75311 The N-terminal domain carries structural determinants essential for agonist and antagonist binding. TM2 is thought to form the innert wall of the chloride channel. The cytoplasmic loop is an important determinant of channel inactivation kinetics.
    SIMILARITY: Belongs to the ligand-gated ionic channel (TC 1.A.9) family.
    MISCELLANEOUS: The alpha subunit binds strychnine.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8°C for up to 12 months.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB15014,Anti-Glycine Receptor α3 subunit Antibody

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