merck millipore,默克密理愽
  • merck millipore,默克密理博,AB17003,Anti-Bim Antibody, internal epitope, pan-Bim isoforms

  • merck millipore,默克密理博,AB17003,Anti-Bim Antibody, internal epitope, pan-Bim isoforms

    产品名称：Anti-Bim Antibody, internal epitope, pan-Bim isoforms
    产品型号：AB17003
    This Anti-Bim Antibody, internal epitope, pan-Bim isoforms is validated for use in WB for the detection of Bim.

    merck millipore,默克密理博,AB17003,Anti-Bim Antibody, internal epitope, pan-Bim isoforms

  • 产品介绍
  • merck millipore,默克密理博,AB17003,Anti-Bim Antibody, internal epitope, pan-Bim isoforms

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB17003
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Bim Antibody, internal epitope, pan-Bim isoforms
    Alternate Names
    • BOD
    产品信息
    格式 Purified
    控制
    • Skin/Skin Tumor
    演示 Immunoaffinity Purified immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
    应用
    应用 This Anti-Bim Antibody, internal epitope, pan-Bim isoforms is validated for use in WB for the detection of Bim.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1000-1:2000

    Human K562 cell lysate can be used as a positive control and a 23 kDa band can be detected.

    Optimal working dilutions must be determined by end user.
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids 22-40 of human origin (O'Conneor et al. 1998). The sequence is identical to that of mouse and is different by one amino acid from that of rat.
    表位 internal epitope, pan-Bim isoforms
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes pan-Bim isoforms.
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    纯化方法 Immunoaffinity purified
    UniProt编号
    • O43521
    UniProt汇总 Function: Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
    Subunit structure: Forms heterodimers with a number of antiapoptotic Bcl-2 proteins including MCL1, BCL2, BCL2L1 isoform Bcl-X(L), BCL2A1/BFL-1, and BHRF1. Does not heterodimerize with proapoptotic proteins such as BAD, BOK, BAX or BAK By similarity.
    Subcellular location: Endomembrane system; Peripheral membrane protein By similarity. Note: Associated with intracytoplasmic membranes By similarity.
    Isoform BimEL: Mitochondrion
    Isoform BimL: Mitochondrion
    Isoform BimS: Mitochondrion
    Isoform Bim-alpha1: Mitochondrion
    Tissue specificity: Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney. Ref.3
    Domain: The BH3 motif is required for Bcl-2 binding and cytotoxicity.
    Sequence similarities: Belongs to the Bcl-2 family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 The undiluted antibody solution is stable for approximately 6 months when stored 2–8°C.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB17003,Anti-Bim Antibody, internal epitope, pan-Bim isoforms

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