merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1526P,Anti-Nerve Growth Factor-β Antibody, pain

  • merck millipore,默克密理博,AB1526P,Anti-Nerve Growth Factor-β Antibody, pain

    产品名称：Anti-Nerve Growth Factor-β Antibody, pain
    产品型号：AB1526P
    This Anti-Nerve Growth Factor-β Antibody, pain is validated for use in ELISA, WB, IH, FUNC for the detection of Nerve Growth Factor-β.

    merck millipore,默克密理博,AB1526P,Anti-Nerve Growth Factor-β Antibody, pain

  • 产品介绍
  • merck millipore,默克密理博,AB1526P,Anti-Nerve Growth Factor-β Antibody, pain

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, Ch, H, MIHC, ELISA, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB1526P
    Replaces 04-1119
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Nerve Growth Factor-β Antibody, pain
    Alternate Names
    • NGFbeta
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Lyophilized from PBS. Contains no preservative. Reconstitute to desired volume with sterile distilled water. Suggested concentration 0.5-1.0 mg/mL.
    应用
    应用 This Anti-Nerve Growth Factor-β Antibody, pain is validated for use in ELISA, WB, IH, FUNC for the detection of Nerve Growth Factor-β.
    主要应用
    • Immunohistochemistry
    • ELISA
    • Western Blotting
    应用说明 Immunohistochemistry: 1-2 μg/mL (see suggested protocol).

    Immunoblotting: 1-2 μg/mL

    Bioassays (Inhibition of biological activity in vitro): 1-2 μg/mL

    in vivo animal studies: use neat

    ELISA: 1-2 μg/mL

    Optimal working dilutions must be determined by the end user.

    BIOLOGICAL ACTIVITY:

    This antibody completely inhibits neuron survival and the outgrowth actions of mouse NGF in chicken dorsal root ganglion in vitro.
    生物信息
    免疫原品种 Mouse nerve growth factor-beta purified from salivary glands.
    宿主 Rabbit
    特异性 Nerve growth factor-beta (NGF). Less than 1% cross-reactivity against recombinant human BDNF, NT3 and NT4 by ELISA.
    品种反应性 RatChickenHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002506.2
    Entrez基因汇总 This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.
    基因符号
    • MGC161428
    • NGFB
    • MGC161426
    • HSAN5
    • NGF
    • Beta-NGF
    非反应性品种
    • Bovine
    UniProt编号
    • P01138
    UniProt汇总 FUNCTION: SwissProt: P01138 # Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.
    SIZE: 241 amino acids; 26959 Da
    SUBUNIT: Homodimer.
    SUBCELLULAR LOCATION: Secreted.
    DISEASE: SwissProt: P01138 # Defects in NGFB are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. Hereditary sensory and autonomic neuropathies are characterized by loss of pain sensation in combination with other sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self- mutilation. The autonomic involvement is variable.
    SIMILARITY: SwissProt: P01138 ## Belongs to the NGF-beta family.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at lyophilized material at -20 to -70°C for up to 12 months after date of receipt. After reconstitution maintain at -20 to -70°C in undiluted aliquots for up to six months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 20 µg

    merck millipore,默克密理博,AB1526P,Anti-Nerve Growth Factor-β Antibody, pain

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