merck millipore,默克密理愽
  • merck millipore,默克密理博,662140,DUB Inhibitor IV, b-AP15 - CAS 1009817-63-4 - Calbiochem

  • merck millipore,默克密理博,662140,DUB Inhibitor IV, b-AP15 - CAS 1009817-63-4 - Calbiochem

    产品名称：DUB Inhibitor IV, b-AP15 - CAS 1009817-63-4 - Calbiochem
    产品型号：662140
    The DUB Inhibitor IV, b-AP15 controls the biological activity of DUB. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

    merck millipore,默克密理博,662140,DUB Inhibitor IV, b-AP15 - CAS 1009817-63-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,662140,DUB Inhibitor IV, b-AP15 - CAS 1009817-63-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₁₇N₃O₆1009817-63-4
    描述
    概述 A cell-permeable bis-nitrobenzylidene-piperidinone that inhibits 19S deubiquitinase (DUB) activity (IC50 = 2.1 µM against Ub-AMC hydrolysis) in a reversible manner by directly targeting UCH37/UCH-L5 and USP14, while exhibiting little or no activity toward BAP1, UCH-L1, UCH-L3, USP2, USP7, USP8 (IC50 >100 µM), or POH1/PRN11. Dual UCH37 and USP14 inhibition by a-AP15 results in increased bulk cellular protein ubiquitination level and a blockage of protein proteasomal degradation (Effective conc. ≥770 nM in HCT-116 cells), exactly opposite to the effects seen with USP14 inhibition alone by IU1 (Cat. No. 662210). Effectively suppresses the growth of various tumors in mice (2.5 to 5 mg/kg, i.p. or s.c.) in vivo.
    产品目录编号 662140
    品牌系列 Calbiochem®
    同义词 NSC687852, 3,5-bis((4-Nitrophenyl)methylidene)-1-prop-2-enoylpiperidin-4-one, (3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one, USP14 Inhibitor III, UCH-L5/UCH37 Inhibitor II
    参考
    参考 D'Arcy, P., et al. 2011. Nat. Med. 17, 1636.
    产品信息
    CAS号 1009817-63-4
    形式 Yellow powder
    Hill配方 C₂₂H₁₇N₃O₆
    化学配方 C₂₂H₁₇N₃O₆
    Molar Mass 419.4
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,662140,DUB Inhibitor IV, b-AP15 - CAS 1009817-63-4 - Calbiochem

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