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经验配方 CAS号 C₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄ 36951-72-1 描述 概述 A potent inhibitor of human telomerase (IC50 = 6.5 µM). TMPyP4 binds strongly to DNA quadruplexes by stacking on the G-tetrads at the core of the quadruplex, resulting in telomerase inhibition. Fluoresces intensely in the presence of quadruplex DNA. 产品目录编号 613560 品牌系列 Calbiochem®
同义词 meso-5,10,15,20-Tetrakis-(N-methyl-4-pyridyl)porphine, Tetratosylate 参考 参考 Yamashita, T., et al. 2005. Bioorg. Med. Chem. 13, 2433.
Izbicka, E., et al. 1999. Cancer Res. 59, 639.
Anantha, N.V., et al. 1998. Biochemistry 37, 2709.
Arthanari, H., et al. 1998. Nucleic Acids Res. 26, 3724.
Wheelhouse, R.T., et al. 1998. J. Am. Chem. Soc. 120, 3261.产品信息 CAS号 36951-72-1 具有ATP竞争性 N 形式 Purple solid Hill配方 C₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄ 化学配方 C₄₄H₃₈N₈ · C₂₈H₂₈O₁₂S₄ Molar Mass 1363.6 吸湿 Hygroscopic
可逆 N 结构配方图像 生物信息 主靶 human telomerase 主靶IC50 6.5 µM inhibiting human telomerase 纯度 ≥90% by TLC 理化信息 细胞可渗透 N 溶解度 H₂O 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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