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品种反应性 主要应用 宿主 格式 抗体类型 R, H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 07-403 品牌系列 Upstate
商名 - Upstate
描述 Anti-Cu/Zn-SOD Antibody 产品信息 格式 Serum 控制 - Positive Control Included: Non-Stim A431 Cell Lysate (12-301)
演示 Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative. 应用 应用 Anti-Cu/Zn-SOD Antibody detects level of Cu/Zn-SOD & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Recombinant protein corresponding to full-length human Cu/Zn-SOD (superoxide dismutase) plus an n-terminal methionine 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Cu/Zn-SOD. 同种型 IgG 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000454
Entrez基因汇总 The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. 基因符号 - Cu-Zn
- SOD1
- IPOA
- SOD
- ALS
- homodimer
- ALS1
纯化方法 Unpurified UniProt编号 - P00441
UniProt汇总 FUNCTION: SwissProt: P00441 # Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
COFACTOR: Binds 1 copper ion per subunit. & Binds 1 zinc ion per subunit.
SIZE: 154 amino acids; 15936 Da
SUBUNIT: Homodimer. The pathogenics variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 interact with RNF19A, whereas wild-type protein does not.
SUBCELLULAR LOCATION: Cytoplasm.
PTM: Unlike wild-type protein, the pathogenics variants ALS1 Arg- 38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A; which leads to their proteasomal degradation.
DISEASE: SwissProt: P00441 # Defects in SOD1 are the cause of amyotrophic lateral sclerosis type 1 (ALS1) [MIM:105400]. ALS1 is a familial form of amyotrophic lateral sclerosis, a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of cases leading to familial forms.
SIMILARITY: SwissProt: P00441 ## Belongs to the Cu-Zn superoxide dismutase family.
MISCELLANEOUS: Zinc binding promotes dimerization.产品使用声明 质量保证 routinely evaluated by immunoblot in RIPA lysates from A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 250 µL
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