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merck millipore,默克密理博,565789,γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem
产品名称：γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem
产品型号：565789
The γ-Secretase Inhibitor XX, also referenced under CAS 209984-56-5, controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
merck millipore,默克密理博,565789,γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₆H₂₃F₂N₃O₃ 209984-56-5 描述 概述 A cell-permeable dibenzazepine (dbz) compound that acts as a potent γ-secretase inhibitor and significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 µmol/kg, i.p). 产品目录编号 565789 品牌系列 Calbiochem®
同义词 (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine 参考 参考 Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
van Es, J.H., et al. 2005. Nature 435, 959.
Milano, J., et al. 2004. Toxicol. Sci. 82, 341.产品信息 CAS号 209984-56-5 具有ATP竞争性 N 形式 White solid Hill配方 C₂₆H₂₃F₂N₃O₃ 化学配方 C₂₆H₂₃F₂N₃O₃ Molar Mass 463.4 可逆 N 结构配方图像 生物信息 主靶 γ-secretase 主靶IC50 1.7 nM inhibiting Notch processing in SupT1 cells 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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