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merck millipore,默克密理博,648490,TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem
产品名称：TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem
产品型号：648490
The TRPC3 Channel Inhibitor, Pyr3, also referenced under CAS 1160514-60-2, controls the biological activity of TRPC3 Channel. This small molecule/inhibitor is primarily used for Protease Inhibitors ap More>>
merck millipore,默克密理博,648490,TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₆H₁₁Cl₃F₃N₃O₃ 1160514-60-2 描述 概述 A cell-permeable pyrazole that acts as an equally potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 540 nM by Fura-2; peak current density pA/pF = -1.45 and -7.50, respectively, with or without 3 µM BTP2/Pyr3 by whole cell clamp) and the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) in TRPC3-expressing HEK293 cells (IC50 = 540 nM; by Fura-2; pA/pF = -2.27 and -18.50, respectively, with or without 3 µM BTP2/Pyr3). Pyr3 is also demonstrated to alleviate pressure overload-induced cardiac hypertrophy following TAC (transverse aortic constriction) operation in mice (0.1 mg/kg/day via i.p. osmotic pump) in vivo. A great complement to Pyr 2 (Cat. No. 203890), Pyr6, and Pyr10 in Ca2+ signaling studies. 产品目录编号 648490 品牌系列 Calbiochem®
同义词 Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate, CRAC Channel Inhibitor II, SB-360475 参考 参考 Schleifier, H., et al. 2012. Br J Pharmacol In Press
Kiyonaka, S., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 5400.产品信息 CAS号 1160514-60-2 形式 Dark brown solid Hill配方 C₁₆H₁₁Cl₃F₃N₃O₃ 化学配方 C₁₆H₁₁Cl₃F₃N₃O₃ Molar Mass 456.6 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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