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品种反应性 主要应用 宿主 格式 抗体类型 H WB M Purified Monoclonal Antibody 描述 产品目录编号 MABC64 描述 Anti-DRAM2 Antibody Alternate Names - Transmembrane protein 77
- DNA damage-regulated autophagy modulator protein 2
背景信息 Damage-Regulated Autophagy Modulator (DRAM) is a lysosomal protein that acts as an effector molecule that is critical for autophagy and p53-mediated apoptosis. In humans, there are 5 known proteins that show significant homology to DRAM. The closest of these proteins is DRAM2, which displays 67% conservation when compared to DRAM. However, unlike DRAM, DRAM2 is not induced by p53 or p73. Additionally, it does not modulate autophagy in contrast with DRAM. DRAM2 is known to be co-localized with DRAM in lysosomes, and co-expression with DRAM is shown to significantly increase cell death. 产品信息 格式 Purified 控制 - Human placenta tissue lysate
演示 Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-DRAM2 Antibody detects level of DRAM2 & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Linear peptide corresponding to the human DRAM2 克隆 4H6.1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_848549
基因符号 - TMEM77
- DRAM2
纯化方法 Protein G Purified UniProt编号 - Q6UX65
UniProt汇总 FUNCTION: Induces apoptotic cell death when co-expressed with DRAM1.
SUBCELLULAR LOCALIZATION: Lysosome membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expression is down-regulated in ovarian tumors (at protein level). Widely expressed with highest levels in placenta and heart. Not detected in brain or thymus.产品使用声明 质量保证 Evaluated by Western Blot in human placenta tissue lysate.
Western Blot Analysis: 1 µg/mL dilution detected DRAM2 in 10 µg of human placenta tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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