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品种反应性 主要应用 宿主 格式 抗体类型 B, H, M, R ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 MAB2617 描述 Anti-Kindlin-2 Antibody, clone 3A3 Alternate Names - mitogen inducible gene 2 protein
- Mitogen-inducible gene 2 protein
- Pleckstrin homology domain-containing family C member 1
- fermitin family homolog 2
- kindlin 2
背景信息 The Kindlin family is a group of focal adhesion proteins that have become a point of interest because of their ability to bind and activate integrins. Abnormalities in this ability have linked Kindlin to several diseases, both inherited and acquired, such as Kindler syndrome, cancer, and leukocyte adhesion deficiency. The isoform Kindlin-2 specifically participates in the recruitment of migfilin protein to focal adhesion sites for cell-ECM interactions, coordinates the manufacture of actin and modifications to cell shape. It is also actively involved in connecting ECM adhesion sites and the actin cytoskeleton (Shi, 2007). Kindlin-2 is pervasively expressed throughout tissue. 产品信息 格式 Purified 控制 - HeLa cell lysate
演示 Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. 应用 应用 This Anti-Kindlin-2 Antibody, clone 3A3 is validated for use in WB, IC for the detection of Kindlin-2. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human Kindlin-2. 表位 Unknown 克隆 3A3 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody recognizes Kindlin-2. 同种型 IgG1κ 品种反应性 BovineHumanMouseRat Species Reactivity Note Demonstrated to react with human. Predicted to react with bovine based on 100% sequence homology.
Mouse and rat (98% sequence homology).抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001128471
基因符号 - mig-2
- FERMT2
- KIND2
- Kindlin-2
- MIG-2
- MIG2
- PLEKHC1
- UNC112
- UNC112B
- kindlin-2
纯化方法 Protein G purfied UniProt编号 - Q96AC1
UniProt汇总 FUNCTION: Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites.
SUBUNIT STRUCTURE: Interacts with FBLP1.
SUBCELLULAR LOCATION: Cytoplasm › cell cortex. Cytoplasm › cytoskeleton. Cell junction › focal adhesion. Note: Within actin stress fibers at cell-ECM focal adhesion sites.
TISSUE SPECIFICTY: Ubiquitous. Found in numerous tumor tissues.
INDUCTION: By serum, in lung fetal fibroblast cultured cells.
DOMAIN: The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain.
SEQUENCE SIMILARITIES: Belongs to the kindlin family.
Contains 1 FERM domain.
Contains 1 PH domain.产品使用声明 质量保证 Evaluated by Western Blot in HeLa cell lysate.
Western Blot Analysis: 0.5 µg/ml of this antibody detected Kindlin-2 in 10 µg of HeLa cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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