merck millipore,默克密理愽
  • merck millipore,默克密理博,06-229,Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody

  • merck millipore,默克密理博,06-229,Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody

    产品名称：Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody
    产品型号：06-229
    This Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody is validated for use in IC, WB for the detection of phospho-erbB-2/HER-2 (Tyr1248).

    merck millipore,默克密理博,06-229,Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-229,Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HWB, ICCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-229
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody
    Alternate Names
    • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2,neuro/glioblastoma derived oncogene homolog (avian)
    • CD340 antigen
    • MLN 19
    • NEU proto-oncogene
    • Tyrosine kinase-type cell surface receptor HER2
    • c-erb B2/neu protein
    • neuroblastoma/glioblastoma derived oncogene homolog
    • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)
    背景信息 The ErbB-2 proto-oncogene, also called Neu, EGFR-2 or HER-2, is a member of the transmembrane receptor tyrosine kinase family, which also includes EGF receptor and EGFR-3 (HER-3 or ErbB-3). Although, ErbB-2 does not have any known high-affinity ligands, its kinase activity can be activated without ligand by either overexpression or heteroassociation with other members of the ErbB family. Amplification of the ErbB-2 gene and overexpression of its product has been detected in almost 40% of primary human breast tumors, which correlates with poor prognosis in node positive breast cancer. ErbB-2 overexpression is also observed in ovarian, gastric, salivary and non-small cell lung carcinomas. Because of this, ErbB-2 is one of the major drug targets for breast cancer and other cancer treatments.
    产品信息
    格式 Affinity Purified
    控制
    • EGF treated A431 cells
    演示 Double immunoaffinity purified rabbit polyclonal IgG in buffer containing 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH7.4
    应用
    应用 This Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody is validated for use in IC, WB for the detection of phospho-erbB-2/HER-2 (Tyr1248).
    主要应用
    • Western Blotting
    • Immunocytochemistry
    应用说明 Immunohistochemistry:
    IHC was performed by an independent laboratory.

    Immunocytochemistry:
    2 µg/mL of a previous lot showed positive immunostaining for phospho-erbB2/HER-2 in EGF treated A431 cells.
    生物信息
    免疫原品种 Synthetic phosphopeptide, residues 1243-1255, corresponding to a major auto-phosphorylation (Tyr1248) site of human erbB-2/HER-2 (C-AENPEpYLGLDVPV).
    表位 Tyr1248
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes and is specific for the activated form of erbB-2/HER-2 oncoprotein, MW ~138 kDa.
    同种型 IgG
    品种反应性 RatHuman
    Species Reactivity Note Human. Predicted to cross react with rat based on conservation of immunogenic sequence.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_004448
    Entrez基因汇总 This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
    基因符号
    • TKR1
    • ERBB2
    • HER2
    • C-erbB-2
    • NEU
    • HER-2/neu
    • NGL
    • herstatin
    • erbB-2
    • p185erbB2
    • HER-2
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P04626
    UniProt汇总 FUNCTION:SwissProt: P04626 # Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF- alpha and amphiregulin.
    SIZE: 1255 amino acids; 137910 Da
    SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    PTM: Ligand-binding increases phosphorylation on tyrosine residues (By similarity).
    SIMILARITY: SwissProt: P04626 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot on A431+/-EGF lysates.

    Western Blotting Analysis:
    1:1000 dilution of this antibody detected phospho-erbB2/Her2 on 10 µg of A431+EGF lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20ºC from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,06-229,Anti-phospho-erbB-2/HER-2 (Tyr1248) Antibody

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