merck millipore,默克密理博,HTS026RTA,Ready-to-Assay™ MCH2 Melanin-Concentrating Hormone Receptor Frozen Cells

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merck millipore,默克密理博,HTS026RTA,Ready-to-Assay™ MCH2 Melanin-Concentrating Hormone Receptor Frozen Cells
产品名称：Ready-to-Assay™ MCH2 Melanin-Concentrating Hormone Receptor Frozen Cells
产品型号：HTS026RTA
Human MCHR2 GPCR frozen cells for Calcium Flux FLIPR Assays.

merck millipore,默克密理博,HTS026RTA,Ready-to-Assay™ MCH2 Melanin-Concentrating Hormone Receptor Frozen Cells

产品介绍

merck millipore,默克密理博,HTS026RTA,Ready-to-Assay™ MCH2 Melanin-Concentrating Hormone Receptor Frozen Cells

重要规格表

应用说明	品种	宿主细胞	蛋白靶
Calcium Flux Assays	Human	Chem-1	MCHR2

描述
产品目录编号	HTS026RTA
商名	Ready-to-Assay
描述	Ready-to-Assay™ MCH₂ Melanin-Concentrating Hormone Receptor Frozen Cells
背景信息	Millipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response. Melanin-concentrating hormone (MCH) is a cyclic, 19 amino acid peptide produced in the lateral hypothalamus and other regions of the mammalian brain (Bittencourt et al., 1992). When administered intracerebrally or overexpressed transgenically in rodents, MCH stimulates food intake and weight gain (Ludwig et al., 2001). Two G protein-coupled receptors for MCH, MCH1 and MCH2, have been identified in humans, although rodents appear only to have MCH1 (Tan et al., 2002). Both MCH1 and MCH2 are expressed primarily in brain (An et al., 2001). MCH1 has been demonstrated by genetic and pharmacological methods in rodent models to mediate obesity caused by a high fat diet or leptin deficiency (Borowsky et al., 2002; Segal-Lieberman, et al., 2003; Marsh et al., 2002). However, MCH2 might play a similar role in the species that express it. Millipore’s cloned human MCH2-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant MCH2 expression on the cell surface for functional detection via the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists, antagonists, and modulators at MCH2.

产品信息
部件	Fifty (50) mL of Media Component. Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.
检测方法	Fluorescent

应用
应用	Human MCHR2 GPCR frozen cells for Calcium Flux FLIPR Assays.
应用说明	Calcium Flux Assays

生物信息
品种	Human
Entrez基因编号	AY562946
GPCR类别	A
宿主细胞	Chem-1
蛋白靶	MCHR2
靶子系列	Melanin-concentrating hormone
细胞系类型	Ready-to-Assay

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck-Millipore to request certain information about you and the establishment where the GMOs are being handled.

产品使用声明

使用声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck-Millipore to request certain information about you and the establishment where the GMOs are being handled.