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merck millipore,默克密理博,556770,RNase L Activator - CAS 357618-26-9 - Calbiochem
产品名称：RNase L Activator - CAS 357618-26-9 - Calbiochem
产品型号：556770
The RNase L Activator, also referenced under CAS 357618-26-9, controls the biological activity of Rnase L. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
merck millipore,默克密理博,556770,RNase L Activator - CAS 357618-26-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₆H₁₄N₂O₂S 357618-26-9 描述 概述 A cell-permeable tricyclic fused phenolic compound that induces RNase L dimerization and activation (EC50 = 22 µM) via direct interaction (KD = 12 µM) at the natural activator 2-5A (5'-phosphorylated, 2',5'-oligoadenylates) binding domain. Shown to exhibit broad-spectrum antiviral activity against diverse types of RNA viruses in both murine (EMCV & VSV in MEF) and human (HPIV-3, Sandai, XMRV in HeLa M, HeLa S, and DU145, respectively) cultures, but not in RNase L-deficient MEF culture or HeLa cells expressing inactive RNase L. Although the synthetic compound binds RNase L with a 4- to 6-times slower kinetic and is 44,000-times less potent than a trimer 2-5A (p3A2'p5'A2'p5'A), it is much more permeant and displays no cytotoxicity to MEF or HeLa S cells (50 µM for 24 h). 产品目录编号 556770 品牌系列 Calbiochem®
同义词 C-5950331 参考 参考 Thakur, C.S., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 9585. 产品信息 CAS号 357618-26-9 形式 Off-white solid Hill配方 C₁₆H₁₄N₂O₂S 化学配方 C₁₆H₁₄N₂O₂S Molar Mass 298.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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