merck millipore,默克密理博,ABE244-S,Anti-monomethyl-Histone H3 (Lys36) Antibody, Trial Size

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, M, H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABE244-S
描述	Anti-monomethyl-Histone H3 (Lys36) Antibody, Trial Size
Alternate Names	histone cluster 3, H3, H3K36me1 H3 histone family, member T histone 3, H3
背景信息	Histone H3 is one of four histones that form a core octameric structure that is required for the packaging of DNA into nucleosomes, the most basic level of chromatin arrangement. Histones undergo a number of post-translational modifications (PTM) at their N- and C-terminal tails which can alter chromatin structure and stability, and influence DNA repair and gene expression. Histone H3 undergoes methylation of its lysine and arginine residues, with varying biological outcomes. The lysine 36 residue undergoes mono-, di-, or trimethylation which may be performed by one of many methyltransferase enzymes (SET2, NSD1, NSD2, NSD3, ASH1, SMYD2, SETMAR, KMT3A, and SETD3). Several studies have indicated that methylated lysine 36 residues promote Rpd3S-mediated deacetylation of other histones resulting in gene activation.

产品信息
格式	Affinity Purified
控制	HeLa acid extract and various recombinant Histone proteins
演示	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-monomethyl-Histone H3 (Lys36) Antibody Trial Size is a rabbit polyclonal for detection of Histone H3 monomethylated at lysine 36. Also known as Anti-H3K36me1, this antibody has dot blot (DB) proven specificity & has been validated in WB, IP. Small pack size is ideal for screening applications.
主要应用	Western Blotting
应用说明	Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated monomethyl-Histone H3 (Lys36) from HeLa acid extract. Dot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see table) were probed with Anti-monomethyl-Histone H3 (Lys36) (0.5 µg/mL).

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to the N-terminus of human Histone H3 monomethylated at Lys36.
表位	Monomethylated Lys36
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	This antibody recognizes the N-terminus of Histone H3 monomethylated at Lys36.
品种反应性	RatMouseHuman
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_003484
基因符号	MGC126886 HIST1H3A H3FA HIST1H3B H3FL HIST1H3C H3FC HIST1H3D H3FB HIST1H3E H3FD HIST1H3F H3FI HIST1H3G H3FH HIST1H3H H3FK HIST1H3I H3FF HIST1H3J H3FJ HIST3H3 H3FT H3T
纯化方法	Affinity purified
UniProt编号	Q16695

产品使用声明
质量保证	Evaluated by Western Blot in HeLa acid extract and various recombinant Histone proteins. Western Blot Analysis: 0.05 µg/mL of this antibody detected monomethyl-Histone H3 (Lys36) in 10 µg of HeLa acid extract.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	10 µg

merck millipore,默克密理博,ABE244-S,Anti-monomethyl-Histone H3 (Lys36) Antibody, Trial Size

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