merck millipore,默克密理愽
  • merck millipore,默克密理博,07-2271,Anti-Serine/threonine-protein kinase 39 Antibody

  • merck millipore,默克密理博,07-2271,Anti-Serine/threonine-protein kinase 39 Antibody

    产品名称：Anti-Serine/threonine-protein kinase 39 Antibody
    产品型号：07-2271
    This Serine/threonine-protein kinase 39 antibody is validated for use in WB for the detection of the Serine/threonine-protein kinase 39 protein.

    merck millipore,默克密理博,07-2271,Anti-Serine/threonine-protein kinase 39 Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-2271,Anti-Serine/threonine-protein kinase 39 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 07-2271
    描述 Anti-Serine/threonine-protein kinase 39 Antibody
    Alternate Names
    • proline-alanine-rich STE20-related kinase
    • STE20/SPS1 homolog
    • Serine/threonine-protein kinase 39
    • serine threonine kinase 39 (STE20/SPS1 homolog, yeast)
    • Ste-20-related kinase
    • Ste20-like protein kinase
    • small intestine SPAK-like kinase
    • STE20/SPS1-related proline-alanine-rich protein kinase
    • serine threonine kinase 39
    背景信息 STE20/SPS-1 related proline alanine-rich kinase (SPAK), or commonly known as Serine/threonine-protein kinase 39, is a member of the SPS1 subfamily of STE20 kinases. Serine/threonine-protein kinase 39 is also very highly conserved between species and has been shown to activate the p38 pathways. Serine/threonine-protein kinase 39 also has a caspase cleavage site and these two functions may mean that Serine/threonine-protein kinase 39 plays a role in stress-activated signaling. Serine/threonine-protein kinase 39 expression is up-regulated by androgens in LNCaP human prostate cancer cells and regulated and phosphorylated by WNK1, which controls the stress signaling pathway. It is activated by WNK4 and then has the ability to stimulate the Na-K-2Cl cotransporter, the inactive version does not posses this ability. Recent research has also made a connection between Serine/threonine-protein kinase 39 and regulation of blood pressure.
    产品信息
    格式 Affinity Purified
    控制
    • HEK293 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Serine/threonine-protein kinase 39 antibody is validated for use in WB for the detection of the Serine/threonine-protein kinase 39 protein.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to human Serine/threonine-protein kinase 39.
    宿主 Rabbit
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human.
    Other homologies: Mouse (95% sequence homology). Rat (94% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_037365
    Entrez基因汇总 This gene encodes a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. [provided by RefSeq].
    基因符号
    • DCHT
    • PASK
    • SPAK
    纯化方法 Affinity purified
    UniProt编号
    • Q9UEW8
    UniProt汇总 FUNCTION: May act as a mediator of stress-activated signals.

    CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.

    SUBCELLULAR LOCATION: Cytoplasm Probable. Nucleus Probable. Note: Nucleus when caspase-cleaved Probable.

    TISSUE SPECIFICTY: Predominantly expressed in brain and pancreas followed by heart, lung, kidney, skeletal muscle, liver, placenta and testis.

    DOMAIN: PAPA box (proline-alanine repeats) may target the kinase to a specific subcellular location by facilitating interaction with intracellular proteins such as actin or actin-like proteins.

    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

    Contains 1 protein kinase domain.
    产品使用声明
    质量保证 Evaluated by Western Blot in HEK293 cell lysate.

    Western Blot Analysis: 1:900 dilution of this antibody detected Serine/threonine-protein kinase 39 on 10 µg of HEK293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,07-2271,Anti-Serine/threonine-protein kinase 39 Antibody

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