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merck millipore,默克密理博,539571,InSolution™ Src Inhibitor, PP1 - Calbiochem
产品名称：InSolution™ Src Inhibitor, PP1 - Calbiochem
产品型号：539571
The InSolution™ Src Inhibitor, PP1 controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,539571,InSolution™ Src Inhibitor, PP1 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₆H₁₉N₅ 描述 概述 A cell-permeable pyrazolopyrimidine compound that is shown to inhibit Src family tyrosine kinases Lck, Fyn, Hck, and Src (IC50 = 5, 6, 20, and 170 nM, respectively), as well as non-Src family kinases such as CSK, RIP2, and CK1δ (IC50 = 640 nM, 26 nM, 170 nM, respectively), in in vitro kinase assays. At 1 µM, in vitro kinase activity is reduced by more than 57% for p38α, p38β, CK1δ, CSK, RIP2, and GAK, while exhibiting much lower activity against more than 60 other kinases. Kinetic studies employing Src and [poly Glu-Tyr 4:1] indicate that the inhibition is mixed competitive with respect to the substrate and non-competitive with respect to ATP. PP1 also demonstrates anti-growth properties in several B lymphoma cultures of human and murine origins (IC50 = 2.5 to 8.0 µM) and pediatric brain tumor cells (IC50 = 1.1 to 9.7 µM). 1 mg of Src Inhibitor, PP1 (Cat. No. 567809) is also available. 产品目录编号 539571 品牌系列 Calbiochem®
参考 参考 Ke, J., et.al. 2009. Mol. Cancer 8, 132.
Sikkema, A.H., et al. 2009. Cancer Res. 69, 5987.
Bain, J., et al. 2007. Biochem. J. 408, 297.
Bain, J., et al. 2003. Biochem. J. 371, 199.
Karni, R., et al. 2003. FEBS Lett. 537, 47.
Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695.产品信息 形式 Liquid 配方 A 50 mM (5 mg/355 µl) solution of Src Inhibitor, PP1 (Cat. No. 567809) in DMSO. Hill配方 C₁₆H₁₉N₅ 化学配方 C₁₆H₁₉N₅ Molar Mass 281.36 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥90% by HPLC 安全信息 R相 R: 36/38
Irritating to eyes and skin.储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Irritant
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-20°C). 包装信息 惰性气体下包装 Packaged under inert gas
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