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merck millipore,默克密理博,218850,Casein Kinase I Inhibitor V, LH846 - CAS 639052-78-2 - Calbiochem
产品名称：Casein Kinase I Inhibitor V, LH846 - CAS 639052-78-2 - Calbiochem
产品型号：218850
The Casein Kinase I Inhibitor V, LH846 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,218850,Casein Kinase I Inhibitor V, LH846 - CAS 639052-78-2 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₆H₁₃ClN₂OS 639052-78-2 描述 概述 A cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIδ (IC50 = 290 nM). Exhibits much reduced potency towards CKIε and CKIα isoforms (IC50 =1.3 and 2.5 µM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKIδ-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10 h at 8 µM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms. 产品目录编号 218850 品牌系列 Calbiochem®
同义词 N-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide, N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide 参考 参考 Lee, J.W., et al. 2011. Angew. Chem. Int. Ed. 50, 10608. 产品信息 CAS号 639052-78-2 形式 Light yellow powder Hill配方 C₁₆H₁₃ClN₂OS 化学配方 C₁₆H₁₃ClN₂OS Molar Mass 316.8 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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