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merck millipore,默克密理博,540216,PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem
产品名称：PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem
产品型号：540216
The PTP Inhibitor XVIII, also referenced under CAS 1229246-07-4, controls the biological activity of PTP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applic More>>
merck millipore,默克密理博,540216,PTP Inhibitor XVIII - CAS 1229246-07-4 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₉H₁₀BrF₆NO₃S 1229246-07-4 描述 概述 A cell-permeable thiazolidinedione compound that is shown to inhibit the enzymatic activity of PTP1B, SHP-1, YOP, TC-PTP, and YPTP1 (IC50 = 5, 5.8, 6, 16, and 18 µM, respectively), but not that of LAR even at concentrations as high as 100 µM. Also reported to activate cellular PPAR with an comparable potency seen with troglitazone (Cat. No. 648469). The combined effect of PTP1B inhibition and PPAR activation most likely accounts for the compound's in vivo antiobesity and antihypoglycemic activity when supplemented directly into the daily high fat diet of C57BL/6j jms Slc male mice (2 mg/g food, ~143 mg/kg animal weight or 4.8 mg/animal). 产品目录编号 540216 品牌系列 Calbiochem®
同义词 Protein Tyrosine Phosphatase Inhibitor XIII, 5-(E)-(2-(3,5-Ditrifluoromethylbenzyloxy)-5-bromo)-benzylidene-1,3-thiazolane-2,4-dione, PPAR Activator VII 参考 参考 Bhattarai, B.R., et al. 2009. Bioorg. Med. Chem. Lett. 19, 6161. 产品信息 CAS号 1229246-07-4 形式 Light yellow powder Hill配方 C₁₉H₁₀BrF₆NO₃S 化学配方 C₁₉H₁₀BrF₆NO₃S Molar Mass 526.3 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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