merck millipore,默克密理愽
  • merck millipore,默克密理博,521275,PDK1/Akt/Flt Dual Pathway Inhibitor - CAS 331253-86-2 - Calbiochem

  • merck millipore,默克密理博,521275,PDK1/Akt/Flt Dual Pathway Inhibitor - CAS 331253-86-2 - Calbiochem

    产品名称：PDK1/Akt/Flt Dual Pathway Inhibitor - CAS 331253-86-2 - Calbiochem
    产品型号：521275
    The PDK1/Akt/Flt Dual Pathway Inhibitor, also referenced under CAS 331253-86-2, controls the biological activity of PDK1/Akt/Flt. This small molecule/inhibitor is primarily used for Phosphorylation &  More>>

    merck millipore,默克密理博,521275,PDK1/Akt/Flt Dual Pathway Inhibitor - CAS 331253-86-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,521275,PDK1/Akt/Flt Dual Pathway Inhibitor - CAS 331253-86-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₀H₄N₆O331253-86-2
    描述
    概述 A cell-permeable compound that selectively induces apoptosis in AML (Acute Myelogenous Leukemia) with little effect on normal CD34+ AML progenitor cells. Shown to directly inhibit both PDK1 and Akt activities in in vitro kinase assays in a dose-dependent manner and block cellular phosphorylation of Akt at both Ser473 and Thr308. The dual inhibition nature against both PDK1/Akt and Flt3/PIM signaling pathways allows effective killing of AML cells (Average IC50 = 1.05, 1.91, and 0.43 µM for AML with wild-type Flt3, single mutant ITD/D835, and double mutant Flt3-ITD-TDK, respectively) that are otherwise resistant to inhibitors that target only the PDK1/Akt pathway.
    CAS. Nos. 331253-86-2 and 329710-24-9 (two isomers)
    产品目录编号 521275
    品牌系列 Calbiochem®
    同义词 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one & 10H-Indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one, Akt Inhibitor XXI, PDK1 Inhibitor I, KP372-1
    参考
    参考 Zeng, Z., et al. 2006. Cancer Res. 66, 3737.
    Koul, D., et al. 2006. Mol. Cancer Ther. 5, 637.
    Mandal. M., et al. 2006. Oral Oncol. 42, 430.
    Mandal. M., et al. 2005. Br. J. Cancer 92, 1899.
    产品信息
    CAS号 331253-86-2
    具有ATP竞争性 N
    形式 Yellow solid
    Hill配方 C₁₀H₄N₆O
    化学配方 C₁₀H₄N₆O
    Molar Mass 224.2
    可逆 N
    结构配方图像
    生物信息
    主靶 Both PDK1 and Akt activities
    主靶IC50 1.05, 1.91, and 0.43 µM for AML with wild-type Flt3, single mutant ITD/D835, and double mutant Flt3-ITD-TDK, respectively
    纯度 ≥98% by HPLC (sum of two isomers)
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    S相 S: 26-36

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,521275,PDK1/Akt/Flt Dual Pathway Inhibitor - CAS 331253-86-2 - Calbiochem

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