merck millipore,默克密理愽
  • merck millipore,默克密理博,574102,Sulindac Sulfide - CAS 32004-67-4 - Calbiochem

  • merck millipore,默克密理博,574102,Sulindac Sulfide - CAS 32004-67-4 - Calbiochem

    产品名称：Sulindac Sulfide - CAS 32004-67-4 - Calbiochem
    产品型号：574102
    A cell-permeable, active metabolite of Sulindac.

    merck millipore,默克密理博,574102,Sulindac Sulfide - CAS 32004-67-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,574102,Sulindac Sulfide - CAS 32004-67-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₀H₁₇FO₂S32004-67-4
    描述
    概述 A cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Preferentially inhibits the secretion of Aβ42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L.
    产品目录编号 574102
    品牌系列 Calbiochem®
    同义词 (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic Acid
    参考
    参考 Weggen, S., et al. 2001. Nature 414, 212.
    Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.
    Herrmann, C., et al. 1998. Oncogene 17, 1769.
    Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.
    Arber, N., et al. 1997. Gastroenterology 113, 1892.
    Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.
    产品信息
    CAS号 32004-67-4
    具有ATP竞争性 N
    形式 Yellow-orange solid
    Hill配方 C₂₀H₁₇FO₂S
    化学配方 C₂₀H₁₇FO₂S
    Molar Mass 340.4
    可逆 N
    结构配方图像
    生物信息
    主靶 COX-1
    主靶IC50 ID50 = 500 nM against COX-1
    纯度 ≥98% by TLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    安全信息
    R相 R: 22-42/43-63

    Harmful if swallowed.
    May cause sensitization by inhalation and skin contact.
    Possible risk of harm to the unborn child.
    S相 S: 36

    Wear suitable protective clothing.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful & Carcinogenic / Teratogenic
    储存 +15°C to +30°C
    无需冷冻 No

    merck millipore,默克密理博,574102,Sulindac Sulfide - CAS 32004-67-4 - Calbiochem

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