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品种反应性 主要应用 宿主 格式 抗体类型 R, Am, B, H, Po IHC, WB M Purified Monoclonal Antibody 描述 产品目录编号 CBL188 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Clathrin Antibody, clone CHC5.9 产品信息 格式 Purified 控制 - Positive reactions using HeLa, SV-40 and RVF-SMC cultured cell lines.
演示 The antibody was purified by gel filtration and is presented as 100μg of lyophilysed material. Reconstitute with 1ml distilled water. Final buffer composition is PBS, pH 7.4. 应用 应用 Anti-Clathrin Antibody, clone CHC5.9 is an antibody against Clathrin for use in WB, IH. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Marker for detection of receptor mediated endocytosis
Suitable for frozen sections
Western blotting KNOW SPECIES
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Coated vesicles (clathrin) of bovine brain. 克隆 CHC5.9 宿主 Mouse 特异性 This antibody reacts with the clathrin heavy chain from a diverse range of species. In nervous tissue it cross-reacts with another coated vesicle polypeptide of 190 kDa which is not present in isolated clathrin triskelions. In some epithelial cells of certain species the antibody may cross-react with a cytokeratin component. It detects coated vesicles from different organs and tissues (e.g. brain, ovary, mammary gland). : Recognizes bovine, rat and amphibian 同种型 IgM 品种反应性 RatAmphibianBovineHumanPig 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_004859.3
Entrez基因汇总 Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. 基因符号 - CLH17
- CLH-17
- KIAA0034
- CLTC
- CHC17
- CLTCL2
- Hc
UniProt编号 - Q00610
UniProt汇总 FUNCTION: SwissProt: Q00610 # Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
SIZE: 1675 amino acids; 191615 Da
SUBUNIT: Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat. In the presence of light chains, hub assembly is influenced by both the pH and the concentration of calcium.
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Cytoplasmic side. Membrane, coated pit; Cytoplasmic side. Melanosome. Note=Cytoplasmic face of coated pits and vesicles. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
SIMILARITY: SwissProt: Q00610 ## Belongs to the clathrin heavy chain family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C for up to 12 months from date of receipt. 包装信息 数量 100 µg
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