merck millipore,默克密理博,AB6031,Anti-Integrin alpha-11 Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
R, H, M	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	AB6031
描述	Anti-Integrin alpha-11 Antibody
Alternate Names	Integrin alpha-11
背景信息	Integrin alpha-11 (ITGA11) belongs to a family of cell adhesion molecules, which consist of noncovalent associated alpha-beta heterodimers, and is shown to be overexpressed in the stroma of human non-small-cell lung carcinomas (hNSCLCs). Upon dimerization, this protein is thought to enhance tumorgenicity of hNSCLCs by interacting with matrix collagen and stromal fibroblasts. Progesterone is shown to increase the expression of ITGA11 through mid-gestation and decrease thereafter in Sprague-Dawley rats. It is further indicated that MAPK signaling is associated with the regulation of these integrins.

产品信息
格式	Affinity Purified
控制	Non-boiled & non-B-ME HeLa cell lysate
演示	Purified rabbit polyclonal containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-Integrin alpha-11 Antibody is an antibody against Integrin alpha-11 for use in WB.
主要应用	Western Blotting

生物信息
免疫原品种	Linear peptide corresponding to human Integrin alpha-11.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	RatHumanMouse
Species Reactivity Note	Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_001004439
Entrez基因汇总	This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.
基因符号	ITGA11
纯化方法	Affinity Purified
UniProt编号	Q9UKX5
UniProt汇总	FUNCTION: Integrin alpha-11/beta-1 is a receptor for collagen. SUBUNIT STRUCTURE: Heterodimer of an alpha and a beta subunit. Alpha-11 associates with beta-1. Interacts with RAB21. SUBCELLULAR LOCATION: Membrane. Note: Single-pass type I membrane protein.

产品使用声明
质量保证	Evaluated by Western Blot in HeLa cell lysate. Western Blot Analysis: 1 µg/mL of this antibody detected Integrin alpha-11 in 10 µg of non-boiled & non-B-ME HeLa cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,AB6031,Anti-Integrin alpha-11 Antibody

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