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merck millipore,默克密理博,07-1535,Anti-JMJD1B (NT) Antibody
产品名称：Anti-JMJD1B (NT) Antibody
产品型号：07-1535
Use Anti-JMJD1B (N-terminus) Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC, ELISA to detect JMJD1B (N-terminus) also known as Jumonji domain-containing protein 1B.
merck millipore,默克密理博,07-1535,Anti-JMJD1B (NT) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H ELISA, WB, ICC Rb Purified Polyclonal Antibody 描述 产品目录编号 07-1535 描述 Anti-JMJD1B (NT) Antibody Alternate Names - jumonji domain containing 1B
- JMJD
- Jumonji domain-containing protein 1B
- Nuclear protein 5qNCA
- chromosome 5 open reading frame 7
背景信息 Methylation of histones plays a critical role in regulating chromatin structure and transcription. The JMJD1 (Jumonji domain-containing protein 1) family, also known as JHDM2 (JmjC domain-containing histone demethylation protein 2) family, contains four members: hairless (HR), JMJD1A/JHDM2A, JMJD1B/JHDM2B, and JMJD1C/JHDM2C. JMJD1B has been shown to specifically demethylate mono-methyl and di-methyl histone H3 on lysine9. H3Lys9 methylation is a highly studied histone mark that represses gene expression and implicates JMJD1B as a key regulator of heterochromatin assembly. Deletions in the gene encoding JMJD1B are frequently associated with myeloid leukemias and myelodysplasias, suggesting JMJD1B also may act as a tumor suppressor. 产品信息 格式 Purified 控制 - Raji nuclear extract
演示 Purified rabbit polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. 应用 应用 Use Anti-JMJD1B (N-terminus) Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC, ELISA to detect JMJD1B (N-terminus) also known as Jumonji domain-containing protein 1B. 主要应用 - ELISA
- Western Blotting
- Immunocytochemistry
应用说明 Immunocytochemistry:
HeLa and NIH/3T3 cells incubated with anti-JMJD1B (N-terminus) stained positively on nuclei.
ELISA:
This antibody was reported by an outside laboratory to be suitable for ELISA.生物信息 免疫原品种 The immunogen was a KLH-conjugated synthetic peptide corresponding to the N-terminal region of human JMJD1B. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes human JMJD1B. 品种反应性 MouseHuman Species Reactivity Note Human, mouse. Not tested in other species. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_057688.2
基因符号 - KIAA1082
- 5qNCA
- C5orf7
- EC 1.14.11.-
- JHDM2B
- KDM3B
纯化方法 Protein A chromatography UniProt编号 - Q7LBC6
UniProt汇总 FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
COFACTOR: Binds 1 Fe(2+) ion per subunit By similarity.
SUBCELLULAR LOCATION: NucleusBy similarity.
TISSUE SPECIFICTY: Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.
DOMAIN: Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors By similarity.
MISCELLANEOUS: Its gene is located in the 5q region of the genome which is deleted in del(5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del(5q) tumor suppressor gene.
SEQUENCE SIMILARITIES: Belongs to the JHDM2 histone demethylase family.
Contains 1 JmjC domain.产品使用声明 质量保证 Western Blot Analysis:
1:250 dilution of this antibody detected JMJD1B on 10 µg of Raji nuclear extract.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 6 months at 2-8°C from date of receipt. For long term storage, store at -20ºC. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. 包装信息 数量 100 µg
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