merck millipore,默克密理愽
  • merck millipore,默克密理博,401488,IKK-3 Inhibitor IX - CAS 862812-98-4 - Calbiochem

  • merck millipore,默克密理博,401488,IKK-3 Inhibitor IX - CAS 862812-98-4 - Calbiochem

    产品名称：IKK-3 Inhibitor IX - CAS 862812-98-4 - Calbiochem
    产品型号：401488
    The IKK-3 Inhibitor IX, also referenced under CAS 862812-98-4, controls the biological activity of IKK-3. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

    merck millipore,默克密理博,401488,IKK-3 Inhibitor IX - CAS 862812-98-4 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,401488,IKK-3 Inhibitor IX - CAS 862812-98-4 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₁₉N₃O₅S₂862812-98-4
    描述
    概述 A thiophenecarbonitrile compound that acts as a potent ATP-competitive inhibitor of IKK-3 (IKK-ε, IC50 = 40 nM) with ~20-fold selectivity over PLK1 and more than 125-fold selectivity over a panel of 9 other commonly studied kinases, including IKK-1/2 (IKK-α/β). Reported to be inactive against cytochrome P450 isozymes (IC50 < 50 µM) 1A2, 2D6, 2C9, and 3A4.
    产品目录编号 401488
    品牌系列 Calbiochem®
    同义词 5-(5,6-Dimethoxybenzimidazol-1-yl)-3-(2-methanesulfonyl-benzyloxy)-thiophene-2-carbonitrile
    参考
    参考 Bamborough, P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 6236.
    产品信息
    CAS号 862812-98-4
    具有ATP竞争性 Y
    形式 Beige solid
    Hill配方 C₂₂H₁₉N₃O₅S₂
    化学配方 C₂₂H₁₉N₃O₅S₂
    Molar Mass 469.5
    可逆 N
    结构配方图像
    生物信息
    主靶 IKK-3
    主靶IC50 40 nM against IKK-3 (IKK-ε)
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,401488,IKK-3 Inhibitor IX - CAS 862812-98-4 - Calbiochem

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