merck millipore,默克密理博,ABC499,Anti-Tropomyosin Antibody, isoforms 5a, 5b, Br2, Br3

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, H, R	ICC, WB, IHC	Sh	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABC499
描述	Anti-Tropomyosin Antibody, isoforms 5a, 5b, Br2, Br3
Alternate Names	Tropomyosin-1 Tropomyosin alpha-1 chain Alpha-tropomyosin
背景信息	Tropomyosin, also known as Tropomyosin alpha-1 chain or Alpha-tropomyosin, or Tropomyosin-1, and encoded by the gene Tpm1/Tpm-1/TPMA, is one chain of the heterodimer complex of tropomyosin that binds to actin in muscle and non-muscle cells and plays a central role in the troponin complex in muscle regulating the calcium dependent vertebrate striated muscle contraction. In non muscle cells tropomyosin assists in cell structure by stabilizing the actin cytoskeleton filaments. Tropomyosin is localized to the cytoplasm. Tropomyosin is expressed in cardiac and skeletal muscle cells as well as non-muscle cells. Defects in Tropomyosin may be associated with Cardiomyopathy, familial hypertrophic 3 (CMH3)] disease. It is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter-and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.

产品信息
格式	Affinity Purified
演示	Purified sheep polyclonal in pH 7.0 buffer containing 0.05% sodium azide.

应用
应用	This Anti-Tropomyosin Antibody, isoforms 5a, 5b, Br2, Br3 is validated for use in western blotting, IHC & ICC for the detection of Tropomyosin.
主要应用	Immunocytochemistry Western Blotting Immunohistochemistry
应用说明	Western Blotting Analysis: 1 µg/mL from a representative lot detected Tropomyosin in 10 µg of rat brain, human brain, mouse cerebellum, and mouse hypothalamus tissue lysate. Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Tropomyosin in human prostate cancer tissue and human breast cancer tissue. Immunocytochemistry Analysis: A representative lot from an independent laboratory detected Tropomyosin in B35 cells (Schevzov, G., et al. (2011). Bioarchitecture. 1(4):135-164.).

生物信息
免疫原品种	Linear peptide corresponding to exon 1b of mouse Tropomyosin.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Sheep
特异性	This antibody specifically recognizes isoforms 5a, 5b, Br2, and Br3 of Tropomyosin.
品种反应性	MouseHumanRat
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_001157720
基因符号	Tpma Tpm1 Tpm-1
纯化方法	Affinity purified
UniProt编号	P58771

产品使用声明
质量保证	Evaluated by Western Blotting in mouse brain tissue lysate. Western Blotting Analysis: 1 µg/mL of this antibody detected Tropomyosin in 10 µg of mouse brain tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	50 µg

merck millipore,默克密理博,ABC499,Anti-Tropomyosin Antibody, isoforms 5a, 5b, Br2, Br3

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