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经验配方 CAS号 C₂₇H₃₃N₃O₄ 170905-75-6 描述 概述 A potent broad-range inhibitor of matrix metalloproteinases (MMPs). Inhibits MMPs in vitro (Ki = 0.2 nM for MMP-1; Ki = 500 nM for MMP-2; Ki = 20 µM for MMP-3; Ki = 100 nM for MMP-8; and Ki = 100 nM for MMP-9). Also reduces the inflammatory and the hyperproliferative responses that occur following topical phorbol ester application. 产品目录编号 364200 品牌系列 Calbiochem®
同义词 N-[(2R)-2-(Carboxymethyl)-4-methylpentanoyl]-L-tryptophan-(S)-methyl-benzylamide 参考 参考 Sato, N., et al. 2003. J. Natl. Cancer Inst. 95, 327.
Holleran, W.M., et al. 1997. Arch. Dermatol. Res. 289, 138.产品信息 CAS号 170905-75-6 具有ATP竞争性 N 形式 Off-white solid Hill配方 C₂₇H₃₃N₃O₄ 化学配方 C₂₇H₃₃N₃O₄ Molar Mass 463.6 可逆 N 结构配方图像 生物信息 主靶 MMP-1 主靶Ki 0.2 nM for MMP-1; 500 nM for MMP-2; 20 µM for MMP-3; 100 nM for MMP-8; 100 nM for MMP-9 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
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