merck millipore,默克密理博,04-341,Anti-phospho-EGFR (Tyr1173) Antibody, rabbit monoclonal

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merck millipore,默克密理博,04-341,Anti-phospho-EGFR (Tyr1173) Antibody, rabbit monoclonal
产品名称：Anti-phospho-EGFR (Tyr1173) Antibody, rabbit monoclonal
产品型号：04-341
Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-phospho-EGFR (Tyr1173) Antibody, Rabbit is an a More>>

merck millipore,默克密理博,04-341,Anti-phospho-EGFR (Tyr1173) Antibody, rabbit monoclonal

产品介绍

merck millipore,默克密理博,04-341,Anti-phospho-EGFR (Tyr1173) Antibody, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
Human Only	WB	Rb	Purified	Monoclonal Antibody

描述
产品目录编号	04-341
品牌系列	Upstate
商名	Upstate
描述	Anti-phospho-EGFR (Tyr1173) Antibody, rabbit monoclonal
Alternate Names	ERBB, ERBB1, epidermal growth factor receptor ERBB ERBB1

产品信息
格式	Purified
演示	In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.

应用
应用	Please note that this product will not be available for sale after March 15, 2015. Please select one of the other antibodies against this target. Anti-phospho-EGFR (Tyr1173) Antibody, Rabbit is an antibody against phospho-EGFR (Tyr1173) for use in IF, IH(P), IP & WB.
主要应用	Western Blotting

生物信息
免疫原品种	KLH-conjugated synthetic peptide corresponding to the amino acid residues including and surrounding tyrosine 1173 of the human EGF Receptor (EGFR).
宿主	Rabbit
特异性	Recognizes human EGFR phosphorylated on tyrosine residue 1173.
同种型	IgG
品种反应性	Human Only
抗体类型	Monoclonal Antibody
Entrez基因编号	NM_201284.1 NM_005228.3 NM_201282.1 NM_201283.1
基因符号	mENA EGFR ERBB1 ERBB
修改	Phosphorylation
UniProt编号	P00533
UniProt汇总	FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist. SIZE: 1210 amino acids; 134277 Da SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted. TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers. PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980]. SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain. MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation.

产品使用声明
质量保证	Routinely evaluated by immunoblot.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.

储存和货运信息

存储条件

2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.