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经验配方 CAS号 C₂₂H₃₄O₃ 22910-60-7 描述 概述 A cell-permeable anacardic acid (Cat. No. 172050) analog that inhibits protein SUMO (Cat. Nos. 662037, 662039, and 662042) modification (IC50 = 3.0 µM using RanGAP1-C2 as substrate) in an ATP-dependent manner by selectively targeting SUMO-activating enzyme E1 (Cat. Nos. 662073 and 662074) and interfering with E1-SUMO intermediate formation independent of E1 active site cysteine. Both ginkgolic acid and anacardic acid are shown to effectively decrease overall SUMOylation of 293T cellular proteins, including p53, in a dose-dependent manner, while neither compound is effective in affecting overall cellular protein ubiquitination or histone H4K8 acetylation in 293T cultures, although both compounds are shown to inhibit histone lysine acetylation by PCAF (Cat. No. 124026) in cell-free acetylase assays. Also available as a 25 mM solution in DMSO (Cat. No. 508197). 产品目录编号 345887 品牌系列 Calbiochem®
同义词 Histone Acetyltransferase Inhibitor VI, PCAF Inhibitor II, SUMOylation Inhibitor, (Z)-6-(Pentadec-8-enyl)-2-hydroxybenzoic acid, HAT Inhibitor VI 参考 参考 Fukuda, I., et al. 2009. Chem. Biol. 16, 133. 产品信息 CAS号 22910-60-7 形式 White solid Hill配方 C₂₂H₃₄O₃ 化学配方 C₂₂H₃₄O₃ Molar Mass 346.5 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO or EtOH 安全信息 R相 R: 36/37/38
Irritating to eyes, respiratory system and skin.S相 S: 26
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Irritant
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following intitial thaw, aliquot and freeze (-20°C). 包装信息 惰性气体下包装 Packaged under inert gas
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