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merck millipore,默克密理博,FCMAB102P,Milli-Mark Anti-Cyclin B1-PE Antibody, clone GNS3 (8A5D12)
产品名称：Milli-Mark Anti-Cyclin B1-PE Antibody, clone GNS3 (8A5D12)
产品型号：FCMAB102P
This Milli-Mark Anti-Cyclin B1-PE Antibody, clone GNS3 (8A5D12) is validated for use in WB, IP, FC for the detection of Cyclin B1.
merck millipore,默克密理博,FCMAB102P,Milli-Mark Anti-Cyclin B1-PE Antibody, clone GNS3 (8A5D12)
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H FC, WB M Phycoerythrin Monoclonal Antibody 描述 产品目录编号 FCMAB102P 商名 - Milli-Mark
描述 Milli-Mark Anti-Cyclin B1-PE Antibody, clone GNS3 (8A5D12) Alternate Names - G2/mitotic-specific cyclin B1 <br />cyclin B1
背景信息 Regulation of cell cycle progression in eukaryotic cells depends on the expression of cyclin proteins. These proteins are the regulatory subunits of the cell cycle-dependent kinases that are responsible for the phosphorylation of several cellular targets. The B cyclins, when combined with p34cdc2, a catalytic subunit of the cell cycle dependent kinase, form an enzyme that is active at the transition to the G2 phase, attaining maximum level at M phase. At that phase, the complex associates with condensed chromosomes in prophase and metaphase and is degraded at the metaphase/anaphase transition.
Anti-Cyclin B1 may be used for the detection of cyclin B1 expression and for measuring relative differences in cyclin B1 level as a function of cell cycle phase.产品信息 格式 Phycoerythrin 控制 - Jurkat Cells
演示 Protein G purified mouse IgGs conjugated to phycoerythrin in storage buffer PBS, 15mg/mL BSA and 0.1% sodium azide with out Glycerol. 应用 应用 This Milli-Mark Anti-Cyclin B1-PE Antibody, clone GNS3 (8A5D12) is validated for use in WB, IP, FC for the detection of Cyclin B1. 主要应用 - Flow Cytometry
- Western Blotting
生物信息 免疫原品种 Recombinant human cyclin B1 表位 Unknown 克隆 GNS3 (8A5D12) 宿主 Mouse 特异性 This antibody is specific for human cyclin B1, MW 58 kDa. Does not cross-react with cyclin A or cyclin D. 同种型 IgG 品种反应性 MouseHuman Species Reactivity Note Tested and passed on Human. In addition to human, weak species cross-reactivity was observed with mouse. 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_031966
Entrez基因汇总 The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. 基因符号 - cyclin B1
- G2/mitotic-specific cyclin B1
纯化方法 Protein G purfied UniProt编号 - P14635
UniProt汇总 FUNCTION: SwissProt: P14635 # Essential for the control of the cell cycle at the G2/M (mitosis) transition.
SIZE: 433 amino acids; 48337 Da
SUBUNIT: Interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDC2 during mitosis to form an endocytotic complex during interphase.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Centrosome.
DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly destroyed at mitosis.
PTM: Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases.
SIMILARITY: SwissProt: P14635 ## Belongs to the cyclin family. Cyclin AB subfamily.产品使用声明 质量保证 Evaluated by Flow Cytometry on Jurkat cells. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8oC in undiluted aliquots for up to 6 months from date of receipt. Protect from light. 包装信息 数量 100 tests
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