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品种反应性 主要应用 宿主 格式 抗体类型 Rhesus Macaque, H, M, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABD43 描述 Anti-Apelin receptor Antibody Alternate Names - G-Protein Coupled Receptor Hg11
- Apelin Receptor
- Angiotensin Receptor-Like 1
- G-Protein Coupled Receptor Apj
背景信息 The Apelin receptor (APJ receptor) is a Gi/o-coupled protein with significant sequence homology to the angiotensin II type 1 (AT1) receptor. It is activated by apelin peptides (12, 17, or 36 amino acids). The effects of the apelin receptor are mediated mainly through the activation of protein kinase C and calcium signaling. The apelin receptor has been detected in the brain, heart, spleen, thymus, ovary, small intestine, and colon. Several studies have suggested that it is involved in regulating cardiovascular function and glucose homeostasis. 产品信息 格式 Affinity Purified 控制 - Mouse Cerebellum Tissue Lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-Apelin receptor Antibody is validated for use in Western Blotting, IHC(P) for the detection of Apelin receptor. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: 0.5 µg/mL from a representative lot detected Apelin receptor on 10 µg of human cerebellum tissue lysate.
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Apelin receptor in several regions of mouse brain sections.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Apelin receptor. 表位 Cytoplasmic domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Apelin receptor at the cytoplasmic domain. 品种反应性 Rhesus MacaqueHumanMouseRat Species Reactivity Note Demonstrated to react with Human and Mouse. Predicted to react with Rat and Rhesus Macaque based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - Np_005152
Entrez基因汇总 This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified. [provided by RefSeq, Jul 2009]. 基因符号 - Apj
- Aplnr
- Agtrl1
纯化方法 Affinity purified UniProt编号 - P35414
UniProt汇总 FUNCTION: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon.
SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 1 family.产品使用声明 质量保证 Evaluated by Western Blot in mouse cerebellum tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Apelin receptor on 10 µg of mouse cerebellum tissue lysate.储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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