- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H WB M Ascites Monoclonal Antibody 描述 产品目录编号 05-725 品牌系列 Upstate
商名 - Upstate
描述 Anti-53BP1 Antibody, clone BP18 产品信息 格式 Ascites 演示 mouse ascites IgM containing 0.05% sodium azide and 30% glycerol 应用 应用 Detect 53BP1 with Anti-53BP1 Antibody, clone BP18 (Mouse Monoclonal Antibody), that has been shown to work in IP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Mix of three GST fusion proteins corresponding to residues 1-337, 338-671, and 1331-1664, respectively, of human 53BP1 克隆 clone BP18 宿主 Mouse 特异性 53BP1 同种型 IgM 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005657.1
基因符号 - MGC138366
- TP53BP1
- 53BP1
- p53BP1
- p202
- FLJ41424
纯化方法 Ascites UniProt编号 - Q12888
UniProt汇总 FUNCTION: SwissProt: Q12888 # May have a role in checkpoint signaling during mitosis (By similarity). Enhances TP53-mediated transcriptional activation. Binds to sites of DNA damage. Plays a role in the response to DNA damage.
SIZE: 1972 amino acids; 213574 Da
SUBUNIT: Interacts with IFI202A (By similarity). Binds to the central domain of TP53/p53. May form homo-oligomers. Interacts with DCLRE1C. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on 'Ser-139'. Interacts with histone H3 that has been methylated on 'Lys-79'. Does not bind unmethylated histone H3.
SUBCELLULAR LOCATION: Nucleus. Kinetochore. Note=Associated with kinetochores. Both nuclear and cytoplasmic in some cells. Recruited to sites of DNA damage, such as double stand breaks.
PTM: Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. & Phosphorylated in an ATM-dependent manner in response to DNA damage.
SIMILARITY: SwissProt: Q12888 ## Contains 2 BRCT domains.产品使用声明 质量保证 routinely evaluated by immunoblot on whole cell lysates from HeLa cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
上一件merck millipore产品：merck millipore,默克密理博,06-661,Anti-Calreticulin Antibody
下一件merck millipore产品：merck millipore,默克密理博,100050,1400W - CAS 214358-33-5 - Calbiochem
相关产品
merck millipore,默克密理博,AG856,Hepatitis B Virus, Envelope
merck millipore,默克密理博,14-805,Met (Y1248C) Protein, active, 10 µg
merck millipore,默克密理博,69864,pET-28a(+) DNA - Novagen
merck millipore,默克密理博,569600,Stem Cell Factor, Human, Recombinant, E. coli
merck millipore,默克密理博,06-661,Anti-Calreticulin Antibody
merck millipore,默克密理博,100050,1400W - CAS 214358-33-5 - Calbiochem
merck millipore,默克密理博,70794,BugBuster GST•Bind™ Purification Kit
merck millipore,默克密理博,364200,GM 1489
merck millipore,默克密理博,539522,PKCε Translocation Inhibitor Peptide - Calbiochem
merck millipore,默克密理博,554720,trans-Retinoic Acid - CAS 302-79-4 - Calbiochem