merck millipore,默克密理博,239803,Cyclopamine, V. californicum - CAS 4449-51-8

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,239803,Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem
产品名称：Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem
产品型号：239803
A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities.

merck millipore,默克密理博,239803,Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem

产品介绍

merck millipore,默克密理博,239803,Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem

重要规格表

经验配方	CAS号
C₂₇H₄₁NO₂	4449-51-8

描述
概述	A cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. Also available as a 10 mM solution in Ethanol (Cat. No. 239806).
产品目录编号	239803
品牌系列	Calbiochem®
同义词	Shh Signaling Antagonist I

参考
参考	Berman, D.M., et al. 2003. Nature, 425, 846. Thayer, S.P., et al. 2003. Nature, 425, 851. Watkins, D.N., et al. 2003. Nature 422, 313. Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071. Berman, D.M., et al. 2002. Science 297, 1559. Taipale, J., et al. 2000. Nature 406, 1005. Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036. Cooper, M.K., et al. 1998. Science 280, 1603. Incardona, J.P., et al. 1998. Development 125, 3553.

参考

Berman, D.M., et al. 2003. Nature, 425, 846.
Thayer, S.P., et al. 2003. Nature, 425, 851.
Watkins, D.N., et al. 2003. Nature 422, 313.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Berman, D.M., et al. 2002. Science 297, 1559.
Taipale, J., et al. 2000. Nature 406, 1005.
Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
Cooper, M.K., et al. 1998. Science 280, 1603.
Incardona, J.P., et al. 1998. Development 125, 3553.

产品信息
CAS号	4449-51-8
具有ATP竞争性	N
形式	Off-white solid
Hill配方	C₂₇H₄₁NO₂
化学配方	C₂₇H₄₁NO₂
Molar Mass	411.6
可逆	N
结构配方图像

生物信息
主靶	Hh signaling in Shh-light2 assay
主靶IC₅₀	20 nM
纯度	≥97% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO, EtOH, or DMF

GHS安全信息
RTECS	GY0750000

储存和货运信息
货运代码	Shipped with Blue Ice or with Dry Ice
毒性	Carcinogenic / Teratogenic
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.