- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC835 描述 Anti-SDHD Antibody Alternate Names - Succinate-ubiquinone reductase membrane anchor subunit
- Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
- CybS
- CII-4
- QPs3
- Succinate dehydrogenase complex subunit D
- Succinate-ubiquinone oxidoreductase cytochrome b small subunit
背景信息 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial (CybS), also known as CII-4 or QPs3 or Succinate dehydrogenase complex subunit D or Succinate-ubiquinone oxidoreductase cytochrome b small subunit or Succinate-ubiquinone reductase membrane anchor subunit, and encoded by the gene name SDHD or SD14, is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH). Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumorsuppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Detect SDHD using this Anti-SDHD Antibody validated for use in western blotting & ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 2.5 μg/mL from a representative lot detected Anti-SDHD in EL4 cells. 生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to the center region of human Anti-SDHD. 表位 center region 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Mouse 抗体类型 Polyclonal Antibody 基因符号 - SD14
- SDHD
纯化方法 Affinity UniProt编号 - O14521
产品使用声明 质量保证 Evaluated by Western Blotting in EL4 cell lysate.
Western Blotting Analysis: 2 μg/mL of this antibody detected Anti-SDHD in EL4 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,MAB8258,Anti-Influenza A Antibody, nucleoprotein, clone A3
下一件merck millipore产品：merck millipore,默克密理博,05-1242,Anti-trimethyl-Histone H3 (Lys9) Antibody, clone 6F12-H4
相关产品
merck millipore,默克密理博,GM230,Tri-gas Mixer
merck millipore,默克密理博,MAB3315,Anti-MMP-7 Antibody, clone 141-7B2
merck millipore,默克密理博,EZRMGH-45K,Rat/Mouse Growth Hormone ELISA
merck millipore,默克密理博,OP53,Anti-c-Fos (Ab-3) Mouse mAb (CS93.1.18)
merck millipore,默克密理博,MAB8258,Anti-Influenza A Antibody, nucleoprotein, clone A3
merck millipore,默克密理博,05-1242,Anti-trimethyl-Histone H3 (Lys9) Antibody, clone 6F12-H4
merck millipore,默克密理博,218767,Caspase-6 Inhibitor II, Cell-Permeable - Calbiochem
merck millipore,默克密理博,MABC004,Mouse IgG2a Negative Control, clone GC270
merck millipore,默克密理博,ABT292,Anti-POSTN Antibody
merck millipore,默克密理博,239803,Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem