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品种反应性 主要应用 宿主 格式 抗体类型 H WB, ELISA M Purified Monoclonal Antibody 描述 产品目录编号 MAB3315 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-MMP-7 Antibody, clone 141-7B2 Alternate Names - Matrilysin
产品信息 格式 Purified 演示 Purified immunoglobulin. Liquid in 0.1 M sodium phosphate buffer, pH 7.0 containing 2% protease-free bovine serum albumin. 应用 应用 Anti-MMP-7 Antibody, clone 141-7B2 is an antibody against MMP-7 for use in ELISA, WB, IH(P). 主要应用 - Western Blotting
- ELISA
应用说明 Immunoblotting: 10 μg/mL Molecular weight band around 30kDa.
Immunohistochemistry on paraffin-embedded tissue sections: 4-20 μg/mL
EIA
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Rectal carcinoma (SW837) cells. 克隆 141-7B2 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody specifically reacts with precursor form of human MMP-7. Does not cross-react with the active forms of human MMP-7 and human MMP-1, 2, 3, 8, 9 and 13. 同种型 IgG1κ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_002423.3
Entrez基因汇总 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. 基因符号 - EC 3.4.24.23
- MMP7
- MPSL1
- matrin
- MMP-7
- PUMP-1
- Matrin
- PUMP1
UniProt编号 - P09237
UniProt汇总 FUNCTION: SwissProt: P09237 # Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.
COFACTOR: Binds 2 calcium ions per subunit. & Binds 2 zinc ions per subunit.
SIZE: 267 amino acids; 29677 Da
DOMAIN: SwissProt: P09237 The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
SIMILARITY: Belongs to the peptidase M10A family.产品使用声明 销售限制 This product is not available for sale in Japan. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- Manufactured by Daiichi Fine Chemical Co., Ltd
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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