merck millipore,默克密理博,MABE368,Anti-acetyl Histone H2A.Z (Lys4/7/11) Antibody, clone 299/39

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	M	Purified	Monoclonal Antibody

描述
产品目录编号	MABE368
描述	Anti-acetyl Histone H2A.Z (Lys4/7/11) Antibody, clone 299/39
Alternate Names	H2A/z Histone H2A.Z
背景信息	H2A.Z, also known as H2AFZ, is a variant of histone H2A that is highly conserved from yeast to humans. Like other histone variants, H2A.Z is encoded by a unique gene, resulting in a slightly divergent type of H2A with specialized functions. H2A.Z is involved in chromatin compaction by stabilizing the histone octamer within the nucleosome. It promotes gene expression through the creation of an open domain of chromatin that is more easily transcribed. H2A.Z is nonrandomly distributed throughout the genome, targeted primarily to pericentric heterochromatin, but excluded from the inactive X chromosome and the nucleolus. H2A.Z is associated with both euchromatin and facultative heterochromatin. DNA methylation can influence chromatin structure and effect gene silencing by excluding H2A.Z, and likewise, H2A.Z protects genes from DNA methylation. Thus, H2A.Z plays a role in regulating heterochromatin silencing and is involved in transcriptional control.

产品信息
格式	Purified
控制	Sodium Butyrate treated and untreated HeLa acid extract.
演示	Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Anti-acetyl Histone H2A.Z (Lys4/7/11) Antibody, clone 299/39 is a highly specific mouse monoclonal antibody, that targets Histone H2A.Z & has been tested in western blotting & Dot Blot.
主要应用	Western Blotting
应用说明	Dot Blot Analysis: A representative lot detected acetyl-Histone H2A.Z (Lys4/7/11) in acetyl Histone H2A.Z (Lys4/7/11) recombinant protein, and demonstrated a loss of signal in non-acetyl Histone H2A.Z (Prof. J. Trimmer, University of California, Davis.).

生物信息
免疫原品种	Linear peptide corresponding to human acetyl-Histone H2A.Z (Lys4/7/11).
克隆	299/39
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Mouse
特异性	This antibody does not cross react with non-acetyl Histone H2A.Z. Additionally, this antibody does not cross react with acetyl Histone H2A (Lys4/8) or acetyl Histone H4 (Lys 4/7/11) (Prof. J. Trimmer, University of California, Davis.).
同种型	IgG1κ
品种反应性	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_002097
基因符号	H2AZ H2AFZ
纯化方法	Protein G purified
UniProt编号	P0C0S5

产品使用声明
质量保证	Evaluated by Western Blotting in Sodium Butyrate treated and untreated HeLa acid extract. Western Blotting Analysis: 2 µg/mL of this antibody detected acetyl-Histone H2A.Z (Lys4/7/11) in Sodium Butyrate treated HeLa acid extract.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	100 µg

merck millipore,默克密理博,MABE368,Anti-acetyl Histone H2A.Z (Lys4/7/11) Antibody, clone 299/39

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