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merck millipore,默克密理博,401477,IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem
产品名称：IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem
产品型号：401477
The IκB Kinase Inhibitor Peptide, Cell-Permeable controls the biological activity of IκB Kinase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
merck millipore,默克密理博,401477,IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₃₈H₂₂₉N₃₇O₄₅S 描述 概述 A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (< 50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt. 产品目录编号 401477 品牌系列 Calbiochem®
同义词 Ac-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂ 参考 参考 Swaroop, N., et al. 2001. Pharm. Res. 18, 1631.
Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.产品信息 具有ATP竞争性 N 形式 Lyophilized 配方 Supplied as a trifluoroacetate salt. Hill配方 C₁₃₈H₂₂₉N₃₇O₄₅S 化学配方 C₁₃₈H₂₂₉N₃₇O₄₅S Molar Mass 3158.6 吸湿 Hygroscopic
肽序列 Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂ 可逆 N 生物信息 主靶 LPS-induced IκB degradation by IKK in RAW 264.7 cells 主靶IC50 <50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation 纯度 ≥95% by HPLC 理化信息 细胞可渗透 N 溶解度 PBS, pH 7.4 肽序列 Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂ 储存和货运信息 货运代码 Blue Ice Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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