merck millipore,默克密理博,ABE582,Anti-HEXIM1 Antibody

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,ABE582,Anti-HEXIM1 Antibody
产品名称：Anti-HEXIM1 Antibody
产品型号：ABE582
Detect the HEXIM1 protein using this Anti-HEXIM1 validated for use in WB & IF.

merck millipore,默克密理博,ABE582,Anti-HEXIM1 Antibody

产品介绍

merck millipore,默克密理博,ABE582,Anti-HEXIM1 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABE582
描述	Anti-HEXIM1 Antibody
Alternate Names	Menage a quatre protein 1 Protein HEXIM1 Cardiac lineage protein 1 Estrogen down-regulated gene 1 protein Hexamethylene bis-acetamide-inducible protein 1
背景信息	HEXIM1 is a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. HEXIM1 works in cooperation with 7SK snRNA to sequester P-TEFb in a large inactive 7SK snRNP complex, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM1 may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. The 7SK snRNP complex is composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. HEXIM1 also interacts with the N-CoR complex through NCOR1, ESR1, NR3C1, and may interact with NF-kappa-B through REL A. Hexim1 is located in the nucleus where it can bind with alpha-importin, and can also be found in the cytoplasm. Hexim1 is up-regulated by HMBA (hexamethylene bisacetamide) at the protein level and down-regulated by estrogen.

产品信息
格式	Affinity Purified
控制	HeLa cell lysate
演示	Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide and 50% glycerol.

应用
应用	Detect the HEXIM1 protein using this Anti-HEXIM1 validated for use in WB & IF.
主要应用	Western Blotting
应用说明	Immunofluorescence Analysis: A 1:25 dilution from a representative lot detected HEXIM1 in MCF-7 cells.

生物信息
免疫原品种	GST-tagged recombinant protein corresponding to human HEXIM1.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	Human
抗体类型	Polyclonal Antibody
基因符号	MAQ1 HEXIM1 CLP1 EDG1 HIS1
纯化方法	Antigen Affinity purified
UniProt编号	O94992

产品使用声明
质量保证	Evaluated by Western Blotting in HeLa cell lysate. Western Blotting Analysis: A 1:600 dilution of this antibody detected HEXIM1 in 30 µg of HeLa cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.