merck millipore,默克密理愽
  • merck millipore,默克密理博,06-1340,Anti-phospho-IKK-epsilon (Ser172) Antibody

  • merck millipore,默克密理博,06-1340,Anti-phospho-IKK-epsilon (Ser172) Antibody

    产品名称：Anti-phospho-IKK-epsilon (Ser172) Antibody
    产品型号：06-1340
    This Anti-phospho-IKK-epsilon (Ser172) Antibody is validated for use in WB for the detection of phospho-IKK-epsilon (Ser172).

    merck millipore,默克密理博,06-1340,Anti-phospho-IKK-epsilon (Ser172) Antibody

  • 产品介绍
  • merck millipore,默克密理博,06-1340,Anti-phospho-IKK-epsilon (Ser172) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 06-1340
    描述 Anti-phospho-IKK-epsilon (Ser172) Antibody
    Alternate Names
    • IKK-i
    • Inhibitor of nuclear factor kappa-B kinase subunit epsilon
    • I-kappa-B kinase epsilon
    • IKK-E
    • IKK-epsilon
    • IkBKE
    • Inducible I kappa-B kinase
    背景信息 IKK-epsilon (IkappaB kinase-epsilon) is an IKK-related kinase that is essential for activation of IRF-3 triggered by TLR3 and certain virus’. IKK-epsilon has also been linked to TBK1 that is thought to control phosphorylation of Ser172 in response to LPS, poly(I:C), and IL-1alpha which blocks production of Type 1 interferons during viral and bacterial infection. IKK-epsilon has also been found to negatively affect F actin assembly. IKK-epsilon has been linked to signaling in innate immunity and inflammation. Recently, IKK-epsilon was added to the list of breast cancer oncogenes.
    产品信息
    格式 Affinity Purified
    控制
    • CD3+CD28 treated and untreated Jurkat cell lysates
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide and 30% glycerol.
    应用
    应用 This Anti-phospho-IKK-epsilon (Ser172) Antibody is validated for use in WB for the detection of phospho-IKK-epsilon (Ser172).
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 Linear peptide corresponding to human IKKepsilon phosphorylated at Ser172.
    表位 Phosphorylated Ser172
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes IKK-epsilon phosphorylated at Ser172.
    品种反应性 RatHumanMouse
    Species Reactivity Note Demonstrated to react with Human and Mouse. Predicted to react with Rat based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001180251
    Entrez基因汇总 IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM].
    基因符号
    • IKKI
    • IKBKE
    • IKKE
    修改
    • Phosphorylation
    纯化方法 Affinity purified
    UniProt编号
    • Q14164
    UniProt汇总 FUNCTION: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.

    CATALYTIC ACTIVITY: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].

    SUBUNIT STRUCTURE: May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE1. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE1. Interacts with TOPORS; induced by DNA damage. Interacts with CYLD.

    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus › PML body. Note: Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent.

    TISSUE SPECIFICITY: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.

    PTM: Autophosphorylated.

    Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1.

    SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.

    Contains 1 protein kinase domain.

    SEQUENCE CAUTION: The sequence BAA09772.2 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Western Blot in CD3+CD28 treated and untreated Jurkat cell lysates.

    Western Blot Analysis: 1:1,000 dilution of this antibody detected IKK-epsilon on 10 µg of CD3+CD28 treated and untreated Jurkat cell lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,06-1340,Anti-phospho-IKK-epsilon (Ser172) Antibody

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