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品种反应性 主要应用 宿主 格式 抗体类型 Chp, H, R, M ICC, WB, IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 06-1005 描述 Anti-TRIC-A Antibody Alternate Names - NET1
- transmembrane protein 38A
- trimeric intracellular cation channel type A
- Tmem38a
背景信息 TRIC-A (trimeric intracellular cation channel type A), also known as Tmem38A, and sometimes NET1, is one of a number of TRIC channel subtypes that are believed to function as a Ca2+ counter-ion channel. TRIC-A is highly expressed in excitable cells and seems to work in coordination with Ca2+ release to balance transient negative potential. TRIC-A is located on the sarcoplasmic reticulum (SR) and is thought to be regulated by trans-membrane voltage. TRIC-A deficiency may lead to an abundance of Ca2+ and cause volatility in Ca2+ movement across the SR membrane. 产品信息 格式 Affinity Purified 控制 - Human fetal skeletal muscle tissue lysate.
演示 Purified rabbit polyclonal in PBS containing 0.05% sodium azide. 应用 应用 Anti-TRIC-A Antibody detects level of TRIC-A & has been published & validated for use in WB, IH & IC. 主要应用 - Immunocytochemistry
- Western Blotting
- Immunohistochemistry
应用说明 Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Wilkie, G.S., et al. (2011). Mol Cell Proteomics. 10(1):M110.003129-1).
Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC. (Wilkie, G.S., et al. (2011). Mol Cell Proteomics. 10(1):M110.003129-1).生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human TRIC-A. 表位 Cytoplasmic domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the cytoplasmic domain of TRIC-A. 品种反应性 ChimpanzeeHumanRatMouse Species Reactivity Note Demonstrated to react with Human, Rat, and Mouse. Predicted to react with Chimpanzee based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_076979.1
基因符号 - TRICA
- TRIC-A
- MGC3169
纯化方法 Affinity purified UniProt编号 - Q9H6F2
UniProt汇总 FUNCTION: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity).
SUBUNIT STRUCTURE: Homotrimer (By similarity).
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane (By similarity).
DOMAIN: The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.
SEQUENCE SIMILARITIES: Belongs to the TMEM38 family.产品使用声明 质量保证 Evaluated by Western Blot in human fetal skeletal muscle tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected TRIC-A on 10 µg of human fetal skeletal muscle tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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