merck millipore,默克密理愽
  • merck millipore,默克密理博,MABC570,Anti-Sec8 Antibody/Exoc4, clone 2E12

  • merck millipore,默克密理博,MABC570,Anti-Sec8 Antibody/Exoc4, clone 2E12

    产品名称：Anti-Sec8 Antibody/Exoc4, clone 2E12
    产品型号：MABC570
    This Anti-Sec8 Antibody/Exoc4, clone 2E12 is validated for use in Western Blotting and Immunocytochemistry for the detection of Sec8/Exoc4.

    merck millipore,默克密理博,MABC570,Anti-Sec8 Antibody/Exoc4, clone 2E12

  • 产品介绍
  • merck millipore,默克密理博,MABC570,Anti-Sec8 Antibody/Exoc4, clone 2E12

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABC570
    描述 Anti-Sec8 Antibody/Exoc4, clone 2E12
    Alternate Names
    • rSec8
    • Exocyst complex component 4
    • Exocyst complex component Sec8
    背景信息 Sec8/Exoc4 is a component of the exocyst complex which is a multi-protein complex used for docking of exocytic vesicles with fusion sites on the plasma membrane. The exocyst complex is essential for exocytosis which is the process whereby proteins, hormones, transmitters etc. are transported and released to the extracellular environment. The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Sec8/Exoc4 appears to be important for tethering of secretory vesicles to specific regions on the plasma membrane. It seems particularly important in normal development for growth and morphological change by allowing the secretion of matrix metalloproteinases such as MMP2 or MMP9 in discrete locations. Knockdowns exhibit reduced cellular proliferation as well as invasive activities as well. As such Sec8/Exoc4 is important in tumor growth and invasion as well, thus it is also a current target for cancer therapy.
    产品信息
    格式 Purified
    演示 Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Sec8 Antibody/Exoc4, clone 2E12 is validated for use in Western Blotting and Immunocytochemistry for the detection of Sec8/Exoc4.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A 1:50-250 dilution from a representative lot detected Sec8/Exoc4 in HeLa, A431, and NIH/3T3 cells. DyLight® is a registered trademark of Thermo Fisher Scientific.
    Western Blotting Analysis: A representative lot detected Sec8/Exoc4 in HeLa cells treated with EXO70 SiRNA (Liu, J., et al. (2007). Molecular Biol. Cell. 18:4483-4492).
    Western Blotting Analysis: A representative lot detected Sec8/Exoc4 in B16F1 cells treated with siRNA targeting Sec8 (Zhao, Y., et al. (2013). Dev. Cell. 26:266-278).
    Immunocytochemistry Analysis: A representative lot detected Sec8/Exoc4 in HeLa cells transfected with GFP-Exo70 (Liu, J., et al. (2007). Molecular Biol. Cell. 18:4483-4492).
    Immunocytochemistry Analysis: A representative lot detected Sec8/Exoc4 in Rat emreyonic hippocampal neurons (Menchon, S.A., et al. (2011). PLOS ONE. 6(9):e24190 1-11).
    生物信息
    免疫原品种 Recombinant protein corresponding to rat Sec8/Exoc4.
    克隆 2E12
    浓缩 Please refer to lot specific datasheet.
    宿主 Mouse
    同种型 IgG2bκ
    品种反应性 RatHumanMouse
    Species Reactivity Note Human, Mouse, Rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_446327
    基因符号
    • Sec8l1
    • Exoc4
    • Sec8
    纯化方法 Protein G purified
    UniProt编号
    • Q62824
    产品使用声明
    质量保证 Evaluated by Western Blotting in HeLa cell lysate.

    Western Blotting Analysis: 0.5 µg/mL of this antibody detected Sec8/Exoc4 in 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABC570,Anti-Sec8 Antibody/Exoc4, clone 2E12

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