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重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, Ca ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-708 品牌系列 Upstate
商名 - Upstate
描述 Anti-Pals1 Antibody 产品信息 格式 Affinity Purified 应用 应用 Detect Pals1 using this Anti-Pals1 Antibody validated for use in IP, WB & IC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 KLH-conjugated, synthetic peptide (C-YNANKNDDYDNE) corresponding to amino acids 450-461 of human Pals1 (palmitoylated 5 protein), also known as MAGUK p55 subfamily member 5 and stardust (Drosophila). The immunizing sequence is identical in orangutan, chimpanzee, chicken, mouse, rat, canine and fish. 宿主 Rabbit 特异性 Recognizes Pals1 同种型 IgG 品种反应性 RatCanine Species Reactivity Note Predicted to cross-react with human, orangutan, chimpanzee, mouse, chicken and fish based on sequence homology 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_022474.2
Entrez基因汇总 Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001 [PubMed 11311936]). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM] 基因符号 - stardust
- MPP5
- FLJ12615
- PALS1
纯化方法 Immunoaffinity purified UniProt编号 - Q8N3R9
UniProt汇总 FUNCTION: SwissProt: Q8N3R9 # May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of VIL2 to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity).
SIZE: 675 amino acids; 77294 Da
SUBUNIT: Interacts with the LIN7 proteins, CRB3 and MPDZ. Interacts with INADL, PARD6B, SC6A1 and VIL2 (By similarity). Forms a complex with CRB1 and MPP4. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3.
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Intracytoplasmic membrane; Peripheral membrane protein. Note=Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membranes (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1. Localized to the Purkinje cell body and axon.
TISSUE SPECIFICITY: Expressed in the retina (at protein level).DOMAIN:SwissProt: Q8N3R9 The L27 domain 1 functions in targeting to the tight junctions by binding to INADL (By similarity). & The PDZ domain binds to the C-terminus of SC6A1 (By similarity).
SIMILARITY: Belongs to the MAGUK family. & Contains 1 guanylate kinase-like domain. & Contains 2 L27 domains. & Contains 1 PDZ (DHR) domain. & Contains 1 SH3 domain.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 1 year at -20°C from date of shipment 包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,428017,Anti-Lamp1 Mouse mAb (LY1C6)
下一件merck millipore产品：merck millipore,默克密理博,07-225,Anti-TrkB Antibody
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