- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,ABE28,Anti-acetyl-MeCP2 (Lys464) Antibody
产品名称：Anti-acetyl-MeCP2 (Lys464) Antibody
产品型号：ABE28
Use Anti-acetyl-MeCP2 (Lys464) Antibody (Rabbit Polyclonal Antibody) validated in DB, WB, ICC to detect acetyl-MeCP2 (Lys464) also known as Methyl-CpG-binding protein 2, MeCp-2 protein.
merck millipore,默克密理博,ABE28,Anti-acetyl-MeCP2 (Lys464) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, M, H ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE28 描述 Anti-acetyl-MeCP2 (Lys464) Antibody Alternate Names - MeCp2
- Methyl-CpG-binding protein 2
- MeCp-2 protein
背景信息 DNA methyltransferases methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, imprinting, and X chromosome inactivation. Methyl CpG binding proteins (MeCPs) specifically recognize methylated regions of DNA and repress transcription both directly and by association with known corepressor proteins which include members of the histone deacetylase protein families. 产品信息 格式 Affinity Purified 控制 - Non-acetylated and acetylated MeCP2 (Lys464) peptides.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Use Anti-acetyl-MeCP2 (Lys464) Antibody (Rabbit Polyclonal Antibody) validated in DB, WB, ICC to detect acetyl-MeCP2 (Lys464) also known as Methyl-CpG-binding protein 2, MeCp-2 protein. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Western Blot Immunoprecipitation Analysis: A representative lot from an independent laboratory detected MeCP2 in 293 cell lysate derived from p300 co-transfected 293 cells. (Prof. Sassone-Corsi, Center for Epigenetics and Metabolism, University of California, Irvine.)
Immunocytochemistry Analysis: A representative lot from an independent laboratory detected MeCP2 in mouse cortical neurons. (Prof. Sassone-Corsi, Center for Epigenetics and Metabolism, University of California, Irvine.)
Alexa Fluor® is a registered trademark of Molecular Probes Inc.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to mouse MeCP2 acetylated at Lys464. 表位 Acetylated lysine 464 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes MeCP2 acetylated at Lysine 464. 品种反应性 RatMouseHuman Species Reactivity Note Demonstrated to react with Mouse. Predicted to react with Human and Rat based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_034918
Entrez基因汇总 DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. 基因符号 - Mecp2
修改 - Acetylation
纯化方法 Affinity purified UniProt编号 - Q9Z2D6
UniProt汇总 FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A.
SUBUNIT STRUCTURE: Interacts with CDKL5. Interacts with FNBP3.
SUBCELLULAR LOCATION: Nucleus. Note: Colocalized with methyl-CpG in the genome.产品使用声明 质量保证 Evaluated by Dot Blot using non-acetylated and acetylated MeCP2 (Lys464) peptides.
Dot Blot Analysis: 1 µg/mL of this antibody detected MeCP2 using non-acetylated and acetylated MeCP2 (Lys464) peptides.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,SF-1072,miR-190a; Human, Cyanine 3, RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,MERSSTX04,替换电极，1 对
相关产品
merck millipore,默克密理博,71545,BacMagic™ DNA Kit - Novagen
merck millipore,默克密理博,428017,Anti-Lamp1 Mouse mAb (LY1C6)
merck millipore,默克密理博,07-708,Anti-Pals1 Antibody
merck millipore,默克密理博,07-225,Anti-TrkB Antibody
merck millipore,默克密理博,SF-1072,miR-190a; Human, Cyanine 3, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,MERSSTX04,替换电极，1 对
merck millipore,默克密理博,MABC570,Anti-Sec8 Antibody/Exoc4, clone 2E12
merck millipore,默克密理博,ST1561,Anti-CLN3 Rabbit pAb
merck millipore,默克密理博,567731,Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem