merck millipore,默克密理愽
  • merck millipore,默克密理博,567731,Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem

  • merck millipore,默克密理博,567731,Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem

    产品名称：Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem
    产品型号：567731
    The Sphingosine Kinase Inhibitor, also referenced under CAS 1177741-83-1, controls the biological activity of Sphingosine Kinase. This small molecule/inhibitor is primarily used for Cell Signaling app More>>

    merck millipore,默克密理博,567731,Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,567731,Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₁ClN₂OS • HCl1177741-83-1
    描述
    概述 A cell-permeable disubstituted thiazole compound that displays anti-tumor properties. Acts as a potent, substrate competitive, reversible, and highly specific inhibitor of sphingosine kinase (IC50 = 0.5 µM for GST-hSK). Does not affect the kinase activity of hERK2, hPI3K, or PKCα even at concentrations as high as 60 µM. Induces apoptosis in human cancer cells that express the drug transport proteins Pgp or MRP1 (IC50 = ~ 1-5 µM) through inhibiting sphingosine-1-phosphate production.
    产品目录编号 567731
    品牌系列 Calbiochem®
    同义词 2-(p-Hydroxyanilino)-4-(p-chlorophenyl) thiazole, HCl, SK Inhibitor I
    参考
    参考 French, K.J., et al. 2003. Cancer Res. 63, 5962.
    产品信息
    CAS号 1177741-83-1
    具有ATP竞争性 Y
    形式 White solid
    Hill配方 C₁₅H₁₁ClN₂OS • HCl
    化学配方 C₁₅H₁₁ClN₂OS • HCl
    Molar Mass 339.2
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 GST-hsk
    主靶IC50 0.5 µM for GST-hSK
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Carcinogenic / Teratogenic
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,567731,Sphingosine Kinase Inhibitor - CAS 1177741-83-1 - Calbiochem

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